Mechanism of action of Xueping Tablet in treatment of abnormal uterine bleeding:A study based on network pharmacology and molecular docking
Objective:To investigate the potential mechanism of action of Xueping Tablet in the treatment of abnormal uterine bleeding based on network pharmacology and molecular docking.Methods:TCSMP,PubChem,and SwissTargetPrediction databases were used to obtain the chemical components of Xueping Tablet and related targets,and OMIM and GeneCards databases were used to obtain disease targets and intersecting targets.STRING database was used to establish a protein-protein interaction network,and Weishengxin platform was used to perform GO functional enrichment analysis and KEGG pathway enrichment analysis.Molecular docking was used to validate the action of core chemical components and core targets.Results:The above analyses obtained 35 main active com-ponents,470 drug targets,1837 disease targets,and 182 intersecting targets.The core targets included AKT1,TNF,STAT3,EGFR,BCL2,and CASP3.GO functions mainly involved response to oxidative stress,peptide tyrosine phos-phorylation,membrane raft,membrane region,protein tyrosine kinase activity,and nuclear receptor activity,and KEGG pathways mainly included resistance to epidermal growth factor receptor-tyrosine kinase inhibitors,prostate cancer,and the prolactin signaling pathway.Molecular docking showed that chrysophanol had a good binding activity to the targets of AKT1,TNF,STAT3,EGFR,BCL2,and CASP3.Conclusion:This study provides a scientific basis for the active components and mechanism of action of Xueping Tablet in the treatment of abnormal uterine bleeding and a reference for further drug development and clinical application.
abnormal uterine bleedingXueping Tabletmechanism of actionnetwork pharmacologymolecular docking
NETL
NSTL
万方数据
