Medication rule in treatment of autoimmune thyroiditis in the non-hyperthyroidism stage:A study based on data mining
Objective:To investigate the medication rule in the treatment of autoimmune thyroiditis(AIT)in the non-hyperthyroidism stage by performing data mining of traditional Chinese medicine(TCM)prescriptions using Cloud Platform of Ancient and Modern Medical Records V2.3.7.Methods:CNKI,VIP,Wanfang Data,and PubMed were searched for articles on TCM treatment of AIT in the non-hyperthyroidism stage published from Janu-ary 1,2014 to February 29,2024.The articles were screened,and the TCM prescriptions were extracted and ana-lyzed in terms of drug frequency,four properties and five tastes,association rule,and hierarchical clustering.Results:A total of 284 TCM prescriptions for the treatment of AIT in the non-hyperthyroidism stage were included in this study,involving 268 single herbs,with a total frequency of use of 3 195.The top 10 drugs in terms of frequency of use were Prunella vulgaris,Bupleurum chinense,Astragalus membranaceus,Atractylodes macroceph-ala Koidz.,Poria cocos,Radix Paeoniae Alba,Fritillaria thunbergii,Angelica sinensis,Radix Glycyrrhizae,and Codonopsis pilosula.Most drugs had a warm nature,followed by those with a neutral,cold or slightly cold nature,and most drugs had a sweet,biter or pungent taste,mainly entering the liver and spleen meridians.Most drugs had the function of soothing the liver and resolving stagnation.Hierarchical clustering obtained 4 clusters,and the associ-ation rule analysis showed that Prunella vulgaris-Astragalus membranaceus was the most commonly used drug com-bination.Conclusion:In the treatment of AIT in the non-hyperthyroidism stage,TCM emphasizes soothing the liver,invigorating spleen and kidney,resolving static blood,and eliminating goiter and applies the drugs for moving Qi,dr-ying dampness,and activating blood based on the pathological factors such as Qi stagnation,phlegm turbidity,and blood stasis.
autoimmune thyroiditis in the non-hyperthyroidism stagemedication ruledata mining
NETL
NSTL
万方数据
