Investigation on a case of angioneurotic edema with infection caused by 13-valent pneumococcal polysaccharide conjugate vaccine
Objective To understand the cause of an event of a case with angioneurotic edema and concurrent infection after inoculation of 13-valent pneumococcal polysaccharide conjugate vaccine(PPCV13),clarify the event property,and provide reference for vaccine safety observation and standardized processing of similar events.Methods The occurrence,development and outcome of the disease,diagnosis and treatment process of disease,cold chain operation of vaccine,vaccination,the vaccination clinic and the qualification of the vaccination staff were investigated after the vaccination of PPCV13 in the child.Relevant data were collected,and experts were organized to carry out the diagnosis of abnormal vaccination reactions.Results The suspected adverse event following immunization(AEFI)after the child received third dose of PPCV13 vaccination was diagnosed as angoneurotic edema by the experts of the investigation and diagnosis expert group of abnormal reaction to vaccination in Xueccheng district,which has a causal association with PPCV13 and belongs to the abnormal reaction to vaccination.Conclusions The occurrence of angioneurotic edema of this child is related to self-allergic constitution.The symptoms of infection may be caused by the release of inflammatory mediators of angioneurotic edema,or it may be combined with respiratory virus infection.The AEFI monitoring of new vaccines,children with special constitution,and people who received multiple doses of the same vaccine should be strengthened.The training of AEFI diagnosis and treatment ability of clinicians should be enhanced,and the publicity and education of vaccination knowledge should be carried out in parents of children for reducing the harm of adverse reactions.
13-valent pneumococcal polysaccharide conjugate vaccineVaccinationSuspected adverse event following immunizationAngioneurotic edema
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