Establishment and research status of animal model of mycobacterium tuberculosis infection in mice
Tuberculosis(TB)is a chronic infectious disease caused by the respiratory transmission of mycobacterium tuberculosis(MTB),and seriously threatens the public health.Researches on TB are always ongoing,and the use of animal model is a good choice for studying vaccine and drugs of tuberculosis due to ethical considerations.The successful establishment of a mice model of MTB infection is essential for the study of the pathogenesis,immune response and pathological manifestations of tuberculosis.The author of this paper summarizes the establishment,identification and application of mice models of MTB infection,in order to provide reference for the study of TB.
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