Analysis of congenital heart disease of children and associated risk factors of mothers in a county of Xinjiang
Objective To understand the current status of the incidence of congenital heart disease(CHD)in children and its distribution characteristics in a county of Xinjiang,and explore the maternal risk factors associated with the occurrence of CHD in children.Methods On-site screening of congenital heart disease was carried out from 1 August 2023 to 21 December 2023 in children aged 1 to 14 years in a populous county of Xinjiang.There were 196 cases with congenital heart disease diagnosis confirmed,and selected as the case group,and 360 cases of the same classmates who had healthy results of physical examination during the same period of time were selected as the control group.The questionnaire"Questionnaire on the Prevalence of Congenital Heart Disease and Related Risk Factors in Children in Xinjiang Uygur Autonomous Region"was carried out in the study subjects.The univariate analysis and multifactorial logistic regression analysis were used to explore the risk factors associated with congenital heart disease in children.Results A total of 13 268 children were screened,of whom 196 cases were screened positive,with a positive rate of 14.77/1 000.The results of multifactorial analysis showed that consanguineous marriage(OR=6.519),illness during pregnancy(OR=3.268),and negative life events during pregnancy(OR=3.358)were the possible risk factors for CHD(P＜0.05).The education level of high school(OR=0.010),secondary school and university college and above(OR=0.010),full-term delivery(OR=0.281),and occasional(OR=0.033)and consistent folic acid use(OR=0.038)during the 3 months before and after pregnancy were all possible protective factors for CHD(P＜0.05).Conclusions The occurrence of congenital heart diseases in children are associated with multiple factors of mothers.The prevention of congenital heart disease in children should avoid the related risk factors and the health education should be strengthened.
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