电催化活性亚甲基化合物的环丙烷化反应
Electrocatalytic Cyclopropanation of Active Methylene Compounds
揭亮华 1徐海超1
作者信息
- 1. 固体表面物理化学国家重点实验室,福建省化学生物学重点实验室,厦门大学化学与化工学院,福建厦门 361005
- 折叠
摘要
由于三元环结构在中间体、天然产品和药物的合成中发挥着重要作用,这使得开发新的策略以获得环丙烷已变得越来越重要.在此,我们提出了一种通过活性亚甲基化合物和芳基烯烃的分子间脱氢环化合成环丙烷的电催化方法.该电化学过程不需要化学氧化剂,允许从廉价和简单易得的原料中快速获得各种官能团化的环丙烷.
Abstract
The development of novel strategies to access cyclopropanes has become increasingly important due to the vital role of these three-membered ring structures in synthetic intermediates,natural products,and pharmaceuticals.Herein,we present an electrocatalytic method for the synthesis of cyclopropanes through intermolecular dehydrogenative annulation of active methylene compounds and arylalkenes.This electrochemical process requires no chemical oxi-dants,allowing for a speedy access to various functionalized cyclopropanes from inexpensive and readily available materials.
关键词
电化学/有机电合成/催化剂/环丙烷/烯烃Key words
Electrochemistry/Cyclopropane/Catalyst/Alkene/Organic electrosynthesis引用本文复制引用
基金项目
National Natural Science Foundation of China(22225101)
Fundamental Research Funds for the Central Universities(20720210003)
出版年
2024
国家科技期刊平台
NSTL
万方数据