Precision Delivery Using Nanopipette for Single-cell Studies
Nanopipette based scanning probe technique is a versatile tool in non-contact imaging in biology.In addition to the topographic imaging,its capability of localized delivery of bio-active molecules is emerging.In this mini review,we introduce the applications of nanopipette in single-cell researches with a focus on localized delivery.The working principles of three delivery modes including resistive pulse,pressure-driven flow,and electroosmotic flow-driven delivery are summarized and compared.Their applications in single-cell researches are reviewed.The current technical challenges in scanning ion conductance microscopy-based delivery,and their growing influence in medicine and pharmacologic researches are also discussed.
Scanning ion conductance microscopyNanopipetteSingle cell imageLocal delivery
张鹤、Md Maksudur Rahman、陶洋、Joseph W Sampson、任航
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Department of Chemistry,The University of Texas at Austin,Austin,TX 78712,USA
Center for Electrochemistry,The University of Texas at Austin,Austin,TX 78712,USA
Texas Materials Institute,The University of Texas at Austin,Austin,TX 78712,USA
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