The mechanism of low-temperature fogging in the photoelectric seeker of airborne missile is analyzed through theoret-ical analysis and experimental test.It is clarified that the respiration of the sealing structure during the temperature cycle is the main reason for the fogging phenomenon inside the seeker.The relationship between the water vapor content introduced by res-piration and the structural leakage rate of the sealing structure under alternating temperature conditions is further deduced,which shows that the water vapor content introduced by respiration is exponentially positively correlated with the product leakage rate.The higher the leakage rate,the more water vapor is introduced by a single respiration.The higher the content,the easier it is to produce fogging phenomenon.exchange rate,and the easier the fog formation.When the leakage rate is lower than 1×10-6 Pa·m3/s,it can effectively reduce the gas exchange rate caused by respiration during the temperature cycle,and control the total gas exchange amount during temperature cycle screening within an acceptable range.Experimental verification was conducted on the number of temperature cycles required to produce fogging phenomenon under different leakage rates.