Preparation and characterization of SA/AKP/PEG 4000 neural catheter
The implantation of nerve catheter into the injured nerve tissue can promote the recovery of nerve.However,it was difficult to large-scale produce neural catheters with relatively uniform pore size and distribution by wet molding method owing to the limitations of cost and technology.In order to continuously prepare nerve catheter with uniform pore size and distribution,porous nerve catheter scaffolds were prepared using biodegradable polymers of sodium alginate and krill protein as matrix and PEG 4000 as pore-inducing agent through the combination method of low temperature wet molding and freeze drying.Additionally,the structure and properties of the materials were characterized.The results showed that PEG 4000 could reduce the viscosity of solution and improve the thermal stability of the catheter.The cross section of the catheter exhibited a honeycomb structure with pore size from 10 to 20 pm and a maximum porosity of 97％.The catheter was with hydrophilic property,and its absorbent performance firstly increased and then decreased with the increasing content of PEG 4000.The adsorption performance of the catheter was 1 417％,when the content of PEG 4000 ranged from 30％to 40％.
sodium alginatepolyethylene glycolnerve conduitlow temperature coagulation
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万方数据
维普
