Ginsenoside regulation of tumor immunotherapy substances based on network pharmacology and molecular docking
Ginsenosides possess chemical diversity and the enhancement of tumor immunotherapy cognition is not systematic,so it is necessary to systematically reveal the basis and mechanism of ginsenosides enhancing tumor immunotherapy substance.Using network pharmacology and molecular docking methods,the database of ginsenoside chemical components was constructed to screen the active ingredients and regulate the potential mechanism of tumor immunity.The experimental results showed a total of 414 ginsenosides were collected,among which 57 ginsenosides were with potentially active.The target prediction results showed that were 139 intersection targets of 57 ginsenosides and tumor immunity.577 GO items and 145 KEGG pathways were obtained by GO and KEGG pathway enrichment analysis.Molecular docking results showed that ginsenoside Rh3 and RORC,20(S)-Rg3 and VEGFA showed strong binding activities depending on hydrogen bonding force,with binding energies of-11.003 and-8.849 kJ/mol,respectively.The results of mechanism analysis showed 139 intersection targets act on PI3K/Akt,Jak/Stat,MAPK related pathways to regulate tumor immunity.
国家科技期刊平台
NSTL
万方数据
