Recent progress in research and application of engineered implanted cells for biomedical applications

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外文摘要：Background:The core concept of cell engineering is the use of synthetic biological methods to engineer and design genetically modified cells with specific functions,which has revolutionized the biotechnology industry and cell therapy.Implanted cells play an important role in the cell therapy,but the currently used implanted cells are unable to fully meet the needs of researchers and clinicians.Therefore,the construction of engineered implanted cells has become a new research area,with many groups exploring the working principles of implanted cells,allowing them to better exert their repair function.Results:Based on the existing cell engineering platforms,this paper summarizes the main types of chassis cells used in implanted cell engineering,progress in the development of gene editing tools and delivery systems,as well as strategies for the construction of engineered implanted cells.Conclusions:The rational use of synthetic biology methods to program and control the function of implanted cells with high spatiotemporal accuracy provides new ideas for the development of cell therapy,and opens up new possibilities for exploring the mechanism of implanted cell action to allow them to better exert their role in promoting the progress of repair.

外文关键词：

chassis cellscell therapyengineered implanted cellssynthetic biology

作者：

Tianying Chen、Xue Zhang、Qiong Wu

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作者单位：

MOE Key Laboratory of Bioinformatics,School of Life Sciences,Tsinghua University,Beijing 100084,China

Center for Synthetic and Systems Biology,Tsinghua University,Beijing 100084,China

基金：

国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金MIX-UP,a joint NSFC and EU H2020 collaborationIn Europe,MIX-UP has received funding from the European Union's Horizon 2020 research and innovation programme

项目编号：

2018YFA0900100319611330193167009131961133019870294

出版年：

2021

定量生物学(英文版)

CSCD

ISSN：

年,卷(期)：2021.(3)

参考文献量253