In order to standardize the maintenance and transfer operation of locomotive wheels and ensure the operation accuracy of transfer manipulator,the lifting control system of locomotive wheels transfer manipulator based on fuzzy PID was studied.The hardware design used fuzzy PID to set the control system frame.The lift-ing bearing device was arranged according to X,Y and Z axes respectively.In the software design,the lifting parameter value of the transfer manipulator was obtained,and the lifting control process of the transferred ma-nipulator was constructed.The experiment results show that taking the locomotive wheeled maintenance and transferring as the test object,the test is carried out according to the conventional mode and the disturbance mode,which can ensure the lifting accuracy of the transfer manipulator and improve the transfer efficiency.