Ecological restoration measures have a significant impact on biodiversity hotspots.Therefore,quantifying the contribution of desertification control to biodiversity is crucial in the karst region of southwest China.This study employed regression analysis and residual trend analysis to reveal the evolutionary patterns of desertification and biodiversity from 2000 to 2020 in this region.It quantified the contributions of desertification control and other factors to biodiversity.The results indicated that during the study period,desertification in the karst region was mainly classified as mild and moderate levels,with a total area reduction of 102500 km2 at an annual rate of 4900 km2/a.Overall,biodiversity showed an increasing trend,with a mean value of the biodiversity composite index at 0.40,maintaining a moderate level.There was a positive correlation between desertification control and biodiversity,with desertification control contributing 26.39%of the overall impact.Climate change and human activities contributed 52.78%and 47.22%to biodiversity,respectively.This suggests that desertification control has made a positive contribution to biodiversity and provides valuable guidance for future ecological restoration projects and biodiversity conservation.