摘要
目的 探究肿瘤标记物在肺腺癌中的性别差异,为肺腺癌精准化医疗提供相关依据.方法 收集2020年01月01日—2022年1月1日在延边大学附属医院胸外科就诊,经手术明确病理诊断为肺腺癌患者168例,其中男性52例,女性116例.于延边大学附属医院检验科测定肿瘤标记物,查阅相关住院病历获得资料.基于SPSS 23.0统计软件进行数据分析.结果 男性肿瘤标记物阳性率由高到低分别是细胞角蛋白19片段(Cyfra21-1)、神经元特异性烯醇化酶(NSE)、胃泌素释放肽前体(ProGRP)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)、糖类抗原153(CA153);女性肿瘤标记物阳性率由高到低分别是:NSE、Cyfra21-1、CA125、ProGRP、CEA、CA199、CA153;不同性别阳性肿瘤标志物具有差异的是Cy-fra21-1(P<0.05).结论 肺腺癌患者中Cyfra21-1存在性别差异,可作为肺腺癌精准化医疗参考指标.
Abstract
Objective To explore the gender differences of tumor markers in lung adenocarcinoma and provide a relevant basis for precise medical treatment of lung adenocarcinoma.Method From January 1,2020 to January 1,2022,168 patients with lung adenocarcinoma di-agnosed by pathology at the Department of Thoracic Surgery of Yanbian University Affiliated Hospital were collected,including 52 males and 116 females.Tumor markers were measured at the Laboratory of Yanbian University Affiliated Hospital and relevant inpatient medi-cal records were consulted to obtain information.Conduct data analysis based on SPSS 23.0 statistical software.Results The positive rates of male tumor markers ranged from high to low,including cytokeratin 19 fragment(Cyfra21-1),neuron-specific enolase(NSE),gas-trin releasing peptide precursor(ProGRP),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125),and carbohydrate antigen 153(CA153);The positive rates of female tumor markers ranged from high to low,are:NSE,Cy-fra21-1,CA125,ProGRP,CEA,CA199,and CA153;The difference in positive tumor markers between different genders was found in Cy-fra21-1(P<0.05).Conclusion There is a gender difference in Cyfra21-1 among lung adenocarcinoma patients,which can serve as a precise medical reference indicator for lung adenocarcinoma.
基金项目
国家自然科学基金重大科研仪器研制项目(21827812)
国家科技期刊平台
NSTL
万方数据