强直性脊柱炎易感基因的研究进展
Research Progress on Susceptibility Genes of Ankylosing Spondylitis
姜佳彤 1刘天月 1武风云 1王艺潼 1李萌 1宋玉国1
作者信息
- 1. 北华大学 医学技术学院,吉林 吉林 132013
- 折叠
摘要
强直性脊柱炎(ankylosing spondylitis,AS)是由遗传、感染、免疫和环境等多因素共同作用的自身免疫性疾病,其中遗传因素与强直性脊柱炎的发病有着强烈的关联.目前所发现的易感基因与AS的发病机制尚不十分清楚,本文对与之相关的主要组织相容性复合体(major histocompatibility complex,MHC)基因包括HLA-B27基因、TNF-α基因和IFN-γ基因以及非MHC基因包括ERAP1基因和IL-23/IL-17免疫通路相关基因在AS发病的中的作用进行综述,对于进一步了解易感基因与强直性脊柱炎之间的相关性具有重要意义.
Abstract
Ankylosing spondylitis(AS)is an autoimmune disease caused by a combination of genetic,infectious,immune,and environmen-tal factors,among which genetic factors are strongly associated with the onset of AS.At present,the susceptibility genes discovered and the pathogenesis of AS are not very clear.This article reviews the roles of the main histocompatibility complex(MHC)genes related to it,including theHLA-B27 gene,TNF-α gene,and IFN-γ gene,as well as non-MHC genes,including theERAP1 gene and IL-23/IL-17 immune pathway related genes,in the pathogenesis of AS.It is of great significance for further understanding the correlation between sus-ceptibility genes and ankylosing spondylitis.
关键词
强直性脊柱炎/易感基因/主要组织相容性复合体Key words
ankylosing spondylitis/susceptible genes/major histocompatibility complex引用本文复制引用
基金项目
吉林省自然科学基金(YDZJ202201ZYTS152)
出版年
2024
国家科技期刊平台
NSTL
万方数据