首页|Neurotrophins and neural stem cells in posttraumatic brain injury repair

Neurotrophins and neural stem cells in posttraumatic brain injury repair

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising steadily.Although different treatment strategies have been developed and tested to mitigate neurological decline,a definitive cure for these conditions remains elusive.Studies have revealed that vari-ous neurotrophins represented by the brain-derived neurotrophic factor are the key regulators of neuroinflammation,apoptosis,blood-brain barrier permeability,neurite regeneration,and memory function.These factors are instrumental in alleviating neu-roinflammation and promoting neuroregeneration.In addition,neural stem cells(NSC)contribute to nerve repair through inherent neuroprotective and immunomodulatory properties,the release of neurotrophins,the activation of endogenous NSCs,and in-tercellular signaling.Notably,innovative research proposals are emerging to combine BDNF and NSCs,enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after TBI.In this review,we summarize the mechanism of neurotrophins in promoting neurogen-esis and restoring neural function after TBI,comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI,and investigate their interaction with NSCs.This endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI,thereby promoting the progress of TBI therapeutics.

mutual effectneural stem cellsneurological functionneurotrophinstraumatic brain injury

Wenwen Guo、Ke Liu、Yinghua Wang、Xu Ge、Yifan Ma、Jing Qin、Caiqin Zhang、Ya Zhao、Changhong Shi

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Laboratory Animal Center,Fourth Military Medical University,Xi'an,P.R.China

Gansu University of Traditional Chinese Medicine,Lanzhou,P.R.China

Medical College of Yan'an University,Yan'an,P.R.China

Laboratory Animal Foundation Program of MilitaryPromotion Plan of the Air Force Medical UniversityShaanxi Province Innovation Capability Support Plan

SYDW[2018]012020SWAQ112021PT-037

2024

10.1002/ame2.12363

动物模型与实验医学(英文)
中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451
年,卷(期)：2024.7(1)
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