Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents: A narrative review

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外文摘要：Glaucoma,an irreversible optic neuropathy,primarily affects retinal ganglion cells (RGC) and causes vision loss and blindness.The damage to RGCs in glaucoma oc-curs by various mechanisms,including elevated intraocular pressure,oxidative stress,inflammation,and other neurodegenerative processes.As the disease progresses,the loss of RGCs leads to vision loss.Therefore,protecting RGCs from damage and promoting their survival are important goals in managing glaucoma.In this regard,resveratrol (RES),a polyphenolic phytoalexin,exerts antioxidant effects and slows down the evolution and progression of glaucoma.The present review shows that RES plays a protective role in RGCs in cases of ischemic injury and hypoxia as well as in ErbB2 protein expression in the retina.Additionally,RES plays protective roles in RGCs by promoting cell growth,reducing apoptosis,and decreasing oxidative stress in H2O2 -exposed RGCs.RES was also found to inhibit oxidative stress damage in RGCs and suppress the activation of mitogen-activated protein kinase signaling pathways.RES could alleviate retinal function impairment by suppressing the hypoxia-inducible factor-1 alpha/vascular endothelial growth factor and p38/p53 axes while stimulating the PI3K/Akt pathway.Therefore,RES might exert potential therapeutic effects for managing glaucoma by protecting RGCs from damage and promoting their survival.

外文关键词：

glaucomaischemic-reperfusion injuryoxidative stressresveratrolretinal ganglion cells

作者：

Maryam Golmohammadi、Seyed Arash Aghaei Meibodi、Sulieman Ibraheem Shelash Al-Hawary、Jitendra Gupta、Ibrohim B.Sapaev、Mazin A.A.Najm、Marim Alwave、Mozhgan Nazifi、Mohammadreza Rahmani、Mohammad Yasin Zamanian、Gervason Moriasi

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作者单位：

School of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,Iran

Department of Business Administration,Business School,Al al-Bayt University,Mafraq,Jordan

Institute of Pharmaceutical Research,GLA University,Mathura,India

Tashkent Institute of Irrigation and Agricultural Mechanization Engineers,Tashkent,Uzbekistan

New Uzbekistan University,Tashkent,Uzbekistan

Pharmaceutical Chemistry Department,College of Pharmacy,Al-Ayen University,Thi-Qar,Iraq

Medical Technical College,Al-Farahidi University,Baghdad,Iraq

Department of Neurology,Hamadan University of Medical Sciences,Hamadan,Iran

Physiology-Pharmacology Research Center,Research Institute of Basic Medical Sciences,Rafsanjan University of Medical Sciences,Rafsanjan,Iran

Department of Physiology and Pharmacology,School of Medicine,Rafsanjan University of Medical Sciences,Rafsanjan,Iran

Neurophysiology Research Center,Hamadan University of Medical Sciences,Hamadan,Iran

Department of Pharmacology and Toxicology,School of Pharmacy,Hamadan University of Medical Sciences,Hamadan,Iran

Department of Medical Biochemistry,School of Medicine,College of Health Sciences,Mount Kenya University,Thika,Kenya

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出版年：

2024

DOI：

10.1002/ame2.12438

动物模型与实验医学(英文)

中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451

年,卷(期)：2024.7(3)

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