首页|Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

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Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation.Animal models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury,organ preservation strategies,and future donor-based interventions.Important considerations include cost,public opinion regarding the conduct of animal research,translational value,and relevance of the animal model for clinical practice.We present an overview of two porcine mod-els of organ donation: donation following brain death (DBD) and donation following circulatory death (DCD).The cardiovascular anatomy and physiology of pigs closely resembles those of humans,making this species the most appropriate for pre-clinical research.Pigs are also considered a potential source of organs for human heart and kidney xenotransplantation.It is imperative to minimize animal loss during procedures that are surgically complex.We present our experience with these models and de-scribe in detail the use cases,procedural approach,challenges,alternatives,and limi-tations of each model.

animal modelbrain deathcirculatory deathorgan transplantation

Frazer I.Heinis、Shaheed Merani、Nicholas W.Markin、Kim F.Duncan、Michael J.Moulton、Lance Fristoe、William E.Thorell、Raechel A.Sherrick、Tami R.Wells、Matthew T.Andrews、Marian Urban

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School of Natural Resources,Institute of Agriculture and Natural Resources,University of Nebraska-Lincoln,Lincoln,Nebraska,USA

Division of Transplantation and Vascular Surgery,Department of Surgery,University of Nebraska Medical Center,Omaha,Nebraska,USA

Department of Anesthesiology,University of Nebraska Medical Center,Omaha,Nebraska,USA

Division of Cardiothoracic Surgery,Department of Surgery,University of Nebraska Medical Center,Omaha,Nebraska,USA

Clinical Perfusion,Nebraska Medicine-Nebraska Medical Center,Omaha,Nebraska,USA

Department of Neurosurgery,University of Nebraska Medical Center,Omaha,Nebraska,USA

Nutrition and Health Sciences,College of Education and Human Sciences,University of Nebraska-Lincoln,Lincoln,Nebraska,USA

Department of Comparative Medicine,University of Nebraska Medical Center,Omaha,Nebraska,USA

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University of Nebraska Collaborative Initiative Program Team Seed Grant

26685

2024

10.1002/ame2.12411

动物模型与实验医学(英文)
中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451
年,卷(期)：2024.7(3)
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