首页|Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs
Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
维普
Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders,and it is a rapidly growing global public health issue.It is characterized by hyperglyce-mia,a condition involving a high blood glucose level brought on by deficiencies in insulin secretion,decreased activity of insulin,or both.Prolonged effects of diabetes include cardiovascular problems,retinopathy,neuropathy,nephropathy,and vascular altera-tions in both macro-and micro-blood vessels.In vivo and in vitro models have always been important for investigating and characterizing disease pathogenesis,identifying targets,and reviewing novel treatment options and medications.Fully understanding these models is crucial for the researchers so this review summarizes the different ex-perimental in vivo and in vitro model options used to study diabetes and its conse-quences.The most popular in vivo studies involves the small animal models,such as rodent models,chemically induced diabetogens like streptozotocin and alloxan,and the possibility of deleting or overexpressing a specific gene by knockout and transgenic technologies on these animals.Other models include virally induced models,diet/nutri-tion induced diabetic animals,surgically induced models or pancreatectomy models,and non-obese models.Large animals or non-rodent models like porcine (pig),canine (dog),nonhuman primate,and Zebrafish models are also outlined.The in vitro models discussed are murine and human beta-cell lines and pancreatic islets,human stem cells,and organoid cultures.The other enzymatic in vitro tests to assess diabetes include assay of amylase inhibition and inhibition of α-glucosidase activity.
animal modelsdiabetes mellitus type Ⅰdiabetes mellitus type Ⅱin vitro and in vivo models
Yasodha Krishna Janapati、Sunil Junapudi
展开 >
School of Pharmacy & Health Sciences,United States International University-AFRICA (USIU-A),Nairobi,Kenya
Department of Pharmaceutical Chemistry,Geethanjali College of Pharmacy,Keesara,India
万方数据
维普
