首页|MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction

MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction

扫码查看
原文链接
  • 万方数据
  • 维普
Background:Myocardial infarction (MI) is an acute condition in which the heart mus-cle dies due to the lack of blood supply.Previous research has suggested that au-tophagy and angiogenesis play vital roles in the prevention of heart failure after MI,and miR-106a is considered to be an important regulatory factor in MI.But the specific mechanism remains unknown.In this study,using cultured venous endothelial cells and a rat model of MI,we aimed to identify the potential target genes of miR-106a and discover the mechanisms of inhibiting autophagy and angiogenesis.Methods:We first explored the biological functions of miR-106a on autophagy and angiogenesis on endothelial cells.Then we identified ATG7,which was the down-stream target gene of miR-106a .The expression of miR-106a and ATG7 was investi-gated in the rat model of MI.Results:We found that miR-106a inhibits the proliferation,cell cycle,autophagy and angiogenesis,but promoted the apoptosis of vein endothelial cells.Moreover,ATG7 was identified as the target of miR-106a,and ATG7 rescued the inhibition of autophagy and angiogenesis by miR-106a .The expression of miR-106a in the rat model of MI was decreased but the expression of ATG7 was increased in the infarction areas.Conclusion:Our results indicate that miR-106a may inhibit autophagy and angiogenesis by targeting ATG7 .This mechanism may be a potential therapeutic treatment for MI.

angiogenesisATG7autophagymiR-106amiRNAsmyocardial infarction

Guofeng Bai、Jinghao Yang、Weili Liao、Xiaofeng Zhou、Yingting He、Nian Li、Liuhong Zhang、Yifei Wang、Xiaoli Dong、Hao Zhang、Jinchun Pan、Liangxue Lai、Xiaolong Yuan、Xilong Wang

展开 >

Guangdong Provincial Key Laboratory of Laboratory Animals,Guangdong Laboratory Animals Monitoring Institute,Guangzhou,China

Guangdong Laboratory of Lingnan Modern Agriculture,National Engineering Research Center for Breeding Swine Industry,State Key Laboratory of Swine and Poultry Breeding Industry,Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding,College of Animal Science,South China Agricultural University,Guangzhou,Guangdong,China

Huidong County Animal Quarantine and Insp

Department of Cardiology,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Hainan Clinical Medicine Research Institution,Haikou,People's Republic of China

Key Laboratory of Regenerative Biology,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,Guangdong,China

Key Laboratory of Regenerative Biology,Gu

展开 >

National Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationBreed Industry Innovation Park of Guangdong Xiaoerhua PigHainan Provincial Natural Science Foundation

320705422021A15150108732022A15150114552022-4408X1-43010402-0019818MS132

2024

10.1002/ame2.12418

动物模型与实验医学(英文)
中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451
年,卷(期)：2024.7(4)