Animal models of tendon calcification:Past,present,and future

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外文摘要：Tendon calcification is a common clinical condition that frequently occurs as a complication after tendon injury and surgery,or as an expression of fibrodysplasia ossificans progressiva.This condition can be referred to by various names in clinical practice and literature,including tendon ossification,tendon mineralization,heterotopic ossification,and calcific tendonitis.The exact pathogenesis of tendon calcification remains uncertain,but current mainstream research suggests that calcification is mostly cell mediated.To further elucidate the pathogenesis of tendon calcification and to better simulate the overall process,selecting appropriate experimental animal models is important.Numerous animal models have been utilized in various clinical studies,each with its own set of advantages and limitations.In this review,we have discussed the advancements made in research on animal models of tendon calcification,with a focus on the selection of experimental animals,the sites of injury in these models,and the methods employed for modeling.

外文关键词：

animal modelsreviewtendon calcification

作者：

Ruichen Li、Canhao Lai、Hong Luo、Yujian Lan、Xinfang Duan、Dingsu Bao、Zhipeng Hou、Huan Liu、Shijie Fu

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作者单位：

Department of Bone and Joint,The Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou,China

Chengdu University of Traditional Chinese Medicine,Chengdu,China

基金：

Science and Technology Innovation Cooperation Special Programme of Sichuan ProvinceIndustry-University-Research Cooperation FoundationLuzhou Science and Technology Plan ProjectChina Postdoctoral Science FoundationScientific Research Project of Southwest Medical UniversityScientific Research Project of Southwest Medical University

项目编号：

2022YFS0609-C12021CXYZ012021-SYF-252023M7329272021ZKMS0512022QN018

出版年：

2024

DOI：

10.1002/ame2.12439

动物模型与实验医学(英文)

中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451

年,卷(期)：2024.7(4)

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