首页|How can we establish animal models of HIV-associated lymphoma?

How can we establish animal models of HIV-associated lymphoma?

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Human immunodeficiency virus (HIV) infection is strongly associated with a height-ened incidence of lymphomas.To mirror the natural course of human HIV infection,animal models have been developed.These models serve as valuable tools to inves-tigate disease pathobiology,assess antiretroviral and immunomodulatory drugs,ex-plore viral reservoirs,and develop eradication strategies.However,there are currently no validated in vivo models of HIV-associated lymphoma (HAL),hampering progress in this crucial domain,and scant attention has been given to developing animal models dedicated to studying HAL,despite their pivotal role in advancing knowledge.This re-view provides a comprehensive overview of the existing animal models of HAL,which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.

animal modelHIV-associated lymphoma (HAL)human immunodeficiency virus (HIV)immunodeficient miceprimate model

Qing Xiao、Liuyue Zhai、Xiaomei Zhang、Yi Liu、Jun Li、Xiaoqing Xie、Guofa Xu、Sanxiu He、Huihui Fu、Yifeng Tang、Fujie Zhang、Yao Liu

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Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Department of Hematology-Oncology,Chongqing University Cancer Hospital,Chongqing,China

Beijing Ditan Hospital,Capital Medical University,Beijing,China

Chongqing Professional Talents PlanFundamental Research Funds for the Central UniversitiesNatural Science Foundation of Chongqing,China

cstc2022ycjhbgzxm00482022CDJYGRH-001CSTB2022NSCQ-MSX1150

2024

10.1002/ame2.12409

动物模型与实验医学(英文)
中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451
年,卷(期)：2024.7(4)