首页|Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer
Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer
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Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer
Background:Triple-negative breast cancer(TNBC),which is so called because of the lack of estrogen receptors(ER),progesterone receptors(PR),and human epidermal growth factor receptor 2(HER2)receptors on the cancer cells,accounts for 10％-15％of all breast cancers.The heterogeneity of the tumor microenvironment is high.However,the role of plasma cells controlling the tumor migration progression in TNBC is still not fully understood.Methods:We analyzed single-cell RNA sequencing data from five HER2 positive,12 ER positive/PR positive,and nine TNBC samples.The potential targets were validated by immunohistochemistry.Results:Plasma cells were enriched in TNBC samples,which was consistent with validation using data from The Cancer Genome Atlas.Cell communication analysis revealed that plasma cells interact with T cells through the intercellular adhesion mol-ecule 2-integrin-aLb2 complex,and then release interleukin 1 beta(IL1B),as verified by immunohistochemistry,ultimately promoting tumor growth.Conclusion:Our results revealed the role of plasma cells in TNBC and identified IL1B as a new prognostic marker for TNBC.
biomaterialbreast cancerIL1Bplasma cellsscRNA-seq
Wenyan Wang、Gehong Dong、Ziguo Yang、Shaoxiang Li、Jia Li、Lin Wang、Qiang Zhu、Yuchen Wang
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Department of General Surgery,Beijing Tiantan Hospital,Capital Medical University,Beijing,China
Department of Pathology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China
Department of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
biomaterial breast cancer IL1B plasma cells scRNA-seq
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