首页|Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer

Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer

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Background:Triple-negative breast cancer(TNBC),which is so called because of the lack of estrogen receptors(ER),progesterone receptors(PR),and human epidermal growth factor receptor 2(HER2)receptors on the cancer cells,accounts for 10％-15％of all breast cancers.The heterogeneity of the tumor microenvironment is high.However,the role of plasma cells controlling the tumor migration progression in TNBC is still not fully understood.Methods:We analyzed single-cell RNA sequencing data from five HER2 positive,12 ER positive/PR positive,and nine TNBC samples.The potential targets were validated by immunohistochemistry.Results:Plasma cells were enriched in TNBC samples,which was consistent with validation using data from The Cancer Genome Atlas.Cell communication analysis revealed that plasma cells interact with T cells through the intercellular adhesion mol-ecule 2-integrin-aLb2 complex,and then release interleukin 1 beta(IL1B),as verified by immunohistochemistry,ultimately promoting tumor growth.Conclusion:Our results revealed the role of plasma cells in TNBC and identified IL1B as a new prognostic marker for TNBC.

biomaterialbreast cancerIL1Bplasma cellsscRNA-seq

Wenyan Wang、Gehong Dong、Ziguo Yang、Shaoxiang Li、Jia Li、Lin Wang、Qiang Zhu、Yuchen Wang

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Department of General Surgery,Beijing Tiantan Hospital,Capital Medical University,Beijing,China

Department of Pathology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China

Department of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

2024

10.1002/ame2.12445

动物模型与实验医学(英文)
中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451
年,卷(期)：2024.7(5)