Role of short-chain fatty acids in host physiology

扫码查看

原文链接

万方数据
维普

外文标题：Role of short-chain fatty acids in host physiology

外文摘要：Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host health.As important mediators between the gut microbiota and the host,SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics,activating G protein-coupled receptors,and inhibiting pathogenic microbial infections.This review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health,enhancing energy metabolism,mitigating diseases such as cancer,obesity,and diabetes,modulating the gut-brain axis and gut-lung axis,and promoting bone health.

外文关键词：

gut microbiotahostinteraction relationshipshort-chain fatty acids

作者：

Mingyue Liu、Yubo Lu、Guoyu Xue、Le Han、Hanbing Jia、Zi Wang、Jia Zhang、Peng Liu、Chaojuan Yang、Yingjie Zhou

展开 >

作者单位：

Stem Cell Storage Center,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China

School of Electronic Information and Electrical Engineering,Shanghai Jiao Tong University,Shanghai,China

Prevention Health Section,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China

Department of Medical Imaging,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China

Department of Obstetrical,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China

Department of Clinical Laboratory,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China

Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Engineering Medicine,Beihang University,Beijing,China

Department of Obstetrics and Gynecology,Hebei Reproductive Health Hospital,Hebei Women and Children's Health Hospital,Hebei Research Institute For Reproductive Health,Shijiazhuang,China

展开 >

关键词：

gut microbiota host interaction relationship short-chain fatty acids

出版年：

2024

DOI：

10.1002/ame2.12464

动物模型与实验医学(英文)

中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451

年,卷(期)：2024.7(5)