Pharmacological effects of bioactive agents in earthworm extract:A comprehensive review

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外文标题：Pharmacological effects of bioactive agents in earthworm extract:A comprehensive review

外文摘要：This review compiles information from the literature on the chemical composition,pharmacological effects,and molecular mechanisms of earthworm extract(EE)and suggests possibilities for clinical translation of EE.We also consider future trends and concerns in this domain.We summarize the bioactive components of EE,including G-90,lysenin,lumbrokinase,antimicrobial peptides,earthworm serine protease(ESP),and polyphenols,and detail the antitumor,antithrombotic,antiviral,antibacterial,anti-inflammatory,analgesic,antioxidant,wound-healing,antifibrotic,and hypoglyce-mic activities and mechanisms of action of EE based on existing in vitro and in vivo studies.We further propose the potential of EE for clinical translation in anticancer and lipid-modifying therapies,and its promise as source of a novel agent for wound healing and resistance to antibiotic tolerance.The earthworm enzyme lumbrokinase embodies highly effective anticoagulant and thrombolytic properties and has the ad-vantage of not causing bleeding phenomena due to hyperfibrinolysis.Its antifibrotic properties can reduce the excessive accumulation of extracellular matrix.The glycoli-poprotein extract G-90 can effectively scavenge reactive oxygen groups and protect cellular tissues from oxidative damage.Earthworms have evolved a well-developed defense mechanism to fight against microbial infections,and the bioactive agents in EE have shown good antibacterial,fungal,and viral properties in in vitro and in vivo experiments and can alleviate inflammatory responses caused by infections,effec-tively reducing pain.Recent studies have also highlighted the role of EE in lowering blood glucose.EE shows high medicinal value and is expected to be a source of many bioactive compounds.

外文关键词：

antithromboticantitumorbioactive agentearthworm extractpharmacological effects

作者：

Zihan Zhu、Xinyi Deng、Wenqing Xie、Hengzhen Li、Yusheng Li、Zhenhan Deng

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作者单位：

Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,Hunan,China

Xiangya School of Medicine,Central South University,Changsha,Hunan,China

National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan,China

Department of Orthopaedic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China

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关键词：

antithrombotic antitumor bioactive agent earthworm extract pharmacological effects

出版年：

2024

DOI：

10.1002/ame2.12465

动物模型与实验医学(英文)

中国实验动物学会,中国医学科学院医学实验动物研究所

动物模型与实验医学(英文)

ISSN：2096-5451

年,卷(期)：2024.7(5)