首页|Differences in cocaine-induced place preference persistence, locomotion and social behaviors between C57BL/6J and BALB/cJ mice

Differences in cocaine-induced place preference persistence, locomotion and social behaviors between C57BL/6J and BALB/cJ mice

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  • 国家科技期刊平台
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C57BL/6J and BALB/cJ mice display significant differences in sociability and response to drugs,but the phenotypic variability of their susceptibility to cocaine is still not well known.In this study,the differences between these two mice strains in the persistence of cocaine-induced conditioned place preference (CPP),as well as the locomotion and social behaviors after the 24-hour withdrawal from a four-day cocaine (20 mg/kg/day) administration were investigated.The results showed that the cocaine-induced CPP persisted over two weeks in C57BL/6J mice,while it diminished within one week among BALB/cJ mice.After 24-hours of cocaine withdrawal,high levels of locomotion as well as low levels of social interaction and aggressive behavior were found in C57BL/6J mice,but no significant changes were found in BALB/cJ mice,indicating that cocaine-induced CPP persistence,locomotion and social behavior are not consistent between these two strains,and that overall C57BL/6J mice are more susceptible to cocaine than BALB/cJ mice at the tested doses.

CocaineConditioned place preferenceLocomotionSocial behaviorWithdrawal

Jian-Li WANG、Bei WANG、Wen CHEN

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College of Biology Sciences and Engineering, Beifang University of Nationalities, Yinchuan 750021, China

College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China

This research was supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of NingxiaScience Foundation of Beifang University of Nationalities

31260513NZ140772012Y052

2014

10.13918/j.issn.2095-8137.2014.5.426

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2014.35(5)
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