首页|Genomic analysis of indigenous goats in Southwest Asia reveals evidence of ancient adaptive introgression related to desert climate

Genomic analysis of indigenous goats in Southwest Asia reveals evidence of ancient adaptive introgression related to desert climate

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Understanding how evolutionary pressures related to climate change have shaped the current genetic background of domestic animals is a fundamental pursuit of biology.Here,we generated whole-genome sequencing data from native goat populations in Iraq and Pakistan.Combined with previously published data on modern,ancient(Late Neolithic to Medieval periods),and wild Capra species worldwide,we explored the genetic population structure,ancestry components,and signatures of natural positive selection in native goat populations in Southwest Asia(SWA).Results revealed that the genetic structure of SWA goats was deeply influenced by gene flow from the eastern Mediterranean during the Chalcolithic period,which may reflect adaptation to gradual warming and aridity in the region.Furthermore,comparative genomic analysis revealed adaptive introgression of the KITLG locus from the Nubian ibex(C.nubiana)into African and SWA goats.The frequency of the selected allele at this locus was significantly higher among goat populations located near northeastern Africa.These results provide new insights into the genetic composition and history of goat populations in the SWA region.

GoatAdaptationKITLGSouthwest AsiaNubian ibex

Hojjat Asadollahpour Nanaei、Yudong Cai、Akil Alshawi、Jiayue Wen、Tanveer Hussain、Wei-Wei Fu、Nai-Yi Xu、Abdulameer Essa、Johannes A.Lenstra、Xihong Wang、Yu Jiang

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Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China

Department of Internal and Preventive Medicine,College of Veterinary Medicine,University of Baghdad,Iraqi Ministry of Higher Education and Scientific Research,Bagdad 10090,Iraq

Department of Molecular Biology,Virtual University of Pakistan,Lahore 54000,Pakistan

Animal Genetics Resources Department,Directorate of Animal Resources,the Ministry of Iraqi Agriculture,Baghdad 10081,Iraq

Faculty of Veterinary Medicine,Utrecht University,3508 TD Utrecht,The Netherlands

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国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金National Thousand Youth Talents Plan to Y.J

32050410304320021403182205291431572381

2023

10.24272/j.issn.2095-8137.2022.242

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(1)
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