动物学研究2023，Vol.44Issue(1) ：142-152.DOI:10.24272/j.issn.2095-8137.2022.423

Towards magnetism in pigeon MagR:Iron-and iron-sulfur binding work indispensably and synergistically

Yajie Zhou Tianyang Tong Mengke Wei Peng Zhang Fan Fei Xiujuan Zhou Zhen Guo Jing Zhang Huangtao Xu Lei Zhang Shun Wang Junfeng Wang Tiantian Cai Xin Zhang Can Xie
动物学研究2023，Vol.44Issue(1) ：142-152.DOI:10.24272/j.issn.2095-8137.2022.423
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Towards magnetism in pigeon MagR:Iron-and iron-sulfur binding work indispensably and synergistically

Yajie Zhou 1Tianyang Tong 2Mengke Wei 1Peng Zhang 3Fan Fei 3Xiujuan Zhou 3Zhen Guo 4Jing Zhang 3Huangtao Xu 5Lei Zhang 3Shun Wang 6Junfeng Wang 7Tiantian Cai 8Xin Zhang 7Can Xie9
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作者信息

  • 1. Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui 230039,China;High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China
  • 2. Department of Anatomy,Anhui Medical University,Hefei,Anhui 230032,China;High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China
  • 3. High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China;Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230036,China
  • 4. School of Life Sciences,Peking University,Beijing 100871,China
  • 5. High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China
  • 6. Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui 230039,China;High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China;Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230036,China
  • 7. Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui 230039,China;High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China;Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230036,China;International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China
  • 8. Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,250 Longwood Avenue,Boston,MA 02115,USA
  • 9. High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China;Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230036,China;International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China
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Abstract

The ability to navigate long distances is essential for many animals to locate shelter,food,and breeding grounds.Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnetic field.A highly conserved iron-sulfur cluster assembly protein IscA is proposed as an animal magnetoreceptor(MagR).Iron-sulfur cluster binding is also suggested to play an essential role in MagR magnetism and is thus critical in animal magnetoreception.In the current study,we provide evidence for distinct iron binding and iron-sulfur cluster binding in MagR in pigeons,an avian species that relies on the geomagnetic field for navigation and homing.Pigeon MagR showed significantly higher total iron content from both iron-and iron-sulfur binding.Y65 in pigeon MagR was shown to directly mediate mononuclear iron binding,and its mutation abolished iron-binding capacity of the protein.Surprisingly,both iron binding and iron-sulfur binding demonstrated synergistic effects,and thus appear to be integral and indispensable to pigeon MagR magnetism.These results not only extend our current understanding of the origin and complexity of MagR magnetism,but also imply a possible molecular explanation for the huge diversity in animal magnetoreception.

Key words

Animal magnetoreception/Iron-sulfur cluster binding/Iron binding/Magnetism/Magnetoreceptor(MagR)

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基金项目

国家自然科学基金(31640001)

国家自然科学基金(U21A20148)

Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(Y96XC11131)

Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(E26CCG27)

Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(E26CCD15)

出版年

2023
动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
参考文献量53
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