首页|Towards magnetism in pigeon MagR:Iron-and iron-sulfur binding work indispensably and synergistically

Towards magnetism in pigeon MagR:Iron-and iron-sulfur binding work indispensably and synergistically

扫码查看
原文链接
  • 万方数据
The ability to navigate long distances is essential for many animals to locate shelter,food,and breeding grounds.Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnetic field.A highly conserved iron-sulfur cluster assembly protein IscA is proposed as an animal magnetoreceptor(MagR).Iron-sulfur cluster binding is also suggested to play an essential role in MagR magnetism and is thus critical in animal magnetoreception.In the current study,we provide evidence for distinct iron binding and iron-sulfur cluster binding in MagR in pigeons,an avian species that relies on the geomagnetic field for navigation and homing.Pigeon MagR showed significantly higher total iron content from both iron-and iron-sulfur binding.Y65 in pigeon MagR was shown to directly mediate mononuclear iron binding,and its mutation abolished iron-binding capacity of the protein.Surprisingly,both iron binding and iron-sulfur binding demonstrated synergistic effects,and thus appear to be integral and indispensable to pigeon MagR magnetism.These results not only extend our current understanding of the origin and complexity of MagR magnetism,but also imply a possible molecular explanation for the huge diversity in animal magnetoreception.

Animal magnetoreceptionIron-sulfur cluster bindingIron bindingMagnetismMagnetoreceptor(MagR)

Yajie Zhou、Tianyang Tong、Mengke Wei、Peng Zhang、Fan Fei、Xiujuan Zhou、Zhen Guo、Jing Zhang、Huangtao Xu、Lei Zhang、Shun Wang、Junfeng Wang、Tiantian Cai、Xin Zhang、Can Xie

展开 >

Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui 230039,China

High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China

Department of Anatomy,Anhui Medical University,Hefei,Anhui 230032,China

Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230036,China

School of Life Sciences,Peking University,Beijing 100871,China

International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China

Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,250 Longwood Avenue,Boston,MA 02115,USA

展开 >

国家自然科学基金国家自然科学基金Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of SciencesPresidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of SciencesPresidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences

31640001U21A20148Y96XC11131E26CCG27E26CCD15

2023

10.24272/j.issn.2095-8137.2022.423

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(1)
  • 53