动物学研究2023，Vol.44Issue(1) ：153-168.DOI:10.24272/j.issn.2095-8137.2022.254

Defects and asymmetries in the visual pathway of non-human primates with natural strabismus and amblyopia

Feng Liu Zhong-Hao Wang Wanjing Huang Ying Xu Xuan Sang Ruifeng Liu Zhou-Yue Li Ya-Lan Bi Lei Tang Jing-Yi Peng Jia-Ru Wei Zhi-Chao Miao Jian-Hua Yan Sheng Liu
动物学研究2023，Vol.44Issue(1) ：153-168.DOI:10.24272/j.issn.2095-8137.2022.254
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  • 维普
  • 万方数据

Defects and asymmetries in the visual pathway of non-human primates with natural strabismus and amblyopia

Feng Liu 1Zhong-Hao Wang 1Wanjing Huang 1Ying Xu 2Xuan Sang 1Ruifeng Liu 1Zhou-Yue Li 1Ya-Lan Bi 3Lei Tang 1Jing-Yi Peng 1Jia-Ru Wei 1Zhi-Chao Miao 4Jian-Hua Yan 1Sheng Liu5
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作者信息

  • 1. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510060,China
  • 2. Guangdong-Hongkong-Macau Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong 510632,China
  • 3. European Molecular Biology Laboratory,European Bioinformatics Institute(EMBL-EBI),Wellcome Genome Campus,Cambridge CB10 1SD,UK
  • 4. European Molecular Biology Laboratory,European Bioinformatics Institute(EMBL-EBI),Wellcome Genome Campus,Cambridge CB10 1SD,UK;Translational Research Institute of Brain and Brain-Like Intelligence and Department of Anesthesiology,Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine,Shanghai 200081,China
  • 5. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510060,China;Guangdong Province Key Laboratory of Brain Function and Disease,Guangzhou,Guangdong 510080,China
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Abstract

Strabismus and amblyopia are common ophthalmologic developmental diseases caused by abnormal visual experiences.However,the underlying pathogenesis and visual defects are still not fully understood.Most studies have used experimental interference to establish disease-associated animal models,while ignoring the natural pathophysiological mechanisms.This study was designed to investigate whether natural strabismus and amblyopia are associated with abnormal neurological defects.We screened one natural strabismic monkey(Macaca fascicularis)and one natural amblyopic monkey from hundreds of monkeys,and retrospectively analyzed one human strabismus case.Neuroimaging,behavioral,neurophysiological,neurostructural,and genovariation features were systematically evaluated using magnetic resonance imaging(MRI),behavioral tasks,flash visual evoked potentials(FVEP),electroretinogram(ERG),optical coherence tomography(OCT),and whole-genome sequencing(WGS),respectively.Results showed that the strabismic patient and natural strabismic and amblyopic monkeys exhibited similar abnormal asymmetries in brain structure,i.e.,ipsilateral impaired right hemisphere.Visual behavior,visual function,retinal structure,and fundus of the monkeys were impaired.Aberrant asymmetry in binocular visual function and structure between the strabismic and amblyopic monkeys was closely related,with greater impairment of the left visual pathway.Several similar known mutant genes for strabismus and amblyopia were also identified.In conclusion,natural strabismus and amblyopia are accompanied by abnormal asymmetries of the visual system,especially visual neurophysiological and neurostructural defects.Our results suggest that future therapeutic and mechanistic studies should consider defects and asymmetries throughout the entire visual system.

Key words

Non-human primates/Natural disease models/Strabismic patients/Strabismus/Amblyopia

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基金项目

国家自然科学基金(81870682)

国家自然科学基金(81961128021)

国家自然科学基金(81670885)

国家重点研发计划(2022YEF0203200)

国家重点研发计划(2021ZD0200103)

国家重点研发计划(2018YFA0108300)

Guangdong Provincial Key Research and Development Programs(2018B030335001)

Guangdong Provincial Key Research and Development Programs(2018B030337001)

Local Innovative and Research Teams Project of Guangdong(2017BT01S138)

广州市科技计划(202007030011)

广州市科技计划(202007030010)

出版年

2023
动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
参考文献量64
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