Effects of gradient high-field static magnetic fields on diabetic mice

Biao Yu ¹Chao Song ¹Chuan-Lin Feng ²Jing Zhang ²Ying Wang ²Yi-Ming Zhu ³Lei Zhang ¹Xin-Miao Ji ¹Xiao-Fei Tian ³Guo-Feng Cheng ²Wei-Li Chen ³Vitalii Zablotskii ⁴Hua Wang ⁵Xin Zhang⁶

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作者信息

1. High Magnetic Field Laboratory,CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,Anhui 230031,China
2. High Magnetic Field Laboratory,CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,Anhui 230031,China;Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230026,China
3. Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui,230601,China
4. Institute of Physics of the Czech Academy of Sciences,Prague,18221,Czech Republic;International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China
5. Department of Oncology,First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China
6. High Magnetic Field Laboratory,CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,Anhui 230031,China;Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230026,China;Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui,230601,China;International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China
折叠

Abstract

Although 9.4 T magnetic resonance imaging(MRI)has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(＞10 T/m vs.0-10 T/m)on type 1 diabetic(T1D)and type 2 diabetic(T2D)mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m)high SMFs(1.0-8.6 T)had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose ≥16.7 mmol/L),the＞10 T/m gradient high SMFs increased malondialdehyde(P＜0.01)and decreased superoxide dismutase(P＜0.05).However,in the severe T1D mice(blood glucose ≥30.0 mmol/L),the＞10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)＞10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10 T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.

Key words

Type 2 diabetes/Type 1 diabetes/Magnetic resonance imaging(MRI)/Gradient static magnetic field/Quasi-uniform static magnetic field

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基金项目

National Natural Science Foundation of China(U21A20148)

National Natural Science Foundation of China(31900506)

National Natural Science Foundation of China(52007185)

International Partnership Program of the Chinese Academy of Sciences(116134KYSB20210052)

Heye Health Technology Chong Ming Project(HYCMP2021010)

CAS President's International Fellowship Initiative Grant(2022VMA0009)

CASHIPS Director's Fund(BJPY2021A06)

CASHIPS Director's Fund(2021YZGH04)

CASHIPS Director's Fund(YZJJ2020QN26)

CASHIPS Director's Fund(YZJJZX202014)

CASHIPS Director's Fund(YZJJ2021QN32)

CASHIPS Director's Fund(YZJJ2023QN43)

出版年

2023

动物学研究

中国科学院昆明动物研究所中国动物学会

动物学研究

CSTPCDCSCD

影响因子：0.582

ISSN：0254-5853

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