首页|Effects of gradient high-field static magnetic fields on diabetic mice

Effects of gradient high-field static magnetic fields on diabetic mice

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Although 9.4 T magnetic resonance imaging(MRI)has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(＞10 T/m vs.0-10 T/m)on type 1 diabetic(T1D)and type 2 diabetic(T2D)mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m)high SMFs(1.0-8.6 T)had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose ≥16.7 mmol/L),the＞10 T/m gradient high SMFs increased malondialdehyde(P＜0.01)and decreased superoxide dismutase(P＜0.05).However,in the severe T1D mice(blood glucose ≥30.0 mmol/L),the＞10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)＞10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10 T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.

Type 2 diabetesType 1 diabetesMagnetic resonance imaging(MRI)Gradient static magnetic fieldQuasi-uniform static magnetic field

Biao Yu、Chao Song、Chuan-Lin Feng、Jing Zhang、Ying Wang、Yi-Ming Zhu、Lei Zhang、Xin-Miao Ji、Xiao-Fei Tian、Guo-Feng Cheng、Wei-Li Chen、Vitalii Zablotskii、Hua Wang、Xin Zhang

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High Magnetic Field Laboratory,CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,Anhui 230031,China

Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230026,China

Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui,230601,China

Institute of Physics of the Czech Academy of Sciences,Prague,18221,Czech Republic

International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China

Department of Oncology,First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaInternational Partnership Program of the Chinese Academy of SciencesHeye Health Technology Chong Ming ProjectCAS President's International Fellowship Initiative GrantCASHIPS Director's FundCASHIPS Director's FundCASHIPS Director's FundCASHIPS Director's FundCASHIPS Director's FundCASHIPS Director's Fund

U21A201483190050652007185116134KYSB20210052HYCMP20210102022VMA0009BJPY2021A062021YZGH04YZJJ2020QN26YZJJZX202014YZJJ2021QN32YZJJ2023QN43

2023

10.24272/j.issn.2095-8137.2022.460

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(2)
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