首页|Intercross population study reveals that co-mutation of mitfa genes in two subgenomes induces red skin color in common carp(Cyprinus carpio wuyuanensis)

Intercross population study reveals that co-mutation of mitfa genes in two subgenomes induces red skin color in common carp(Cyprinus carpio wuyuanensis)

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Common carp are among the oldest domesticated fish in the world.As such,there are many food and ornamental carp strains with abundant phenotypic variations due to natural and artificial selection.Hebao red carp(HB,Cyprinus carpio wuyuanensis),an indigenous strain in China,is renowned for its unique body morphology and reddish skin.To reveal the genetic basis underlying the distinct skin color of HB,we constructed an improved high-fidelity(HiFi)HB genome with good contiguity,completeness,and correctness.Genome structure comparison was conducted between HB and a representative wild strain,Yellow River carp(YR,C.carpio haematopterus),to identify structural variants and genes under positive selection.Signatures of artificial selection during domestication were identified in HB and YR populations,while phenotype mapping was performed in a segregating population generated by HBxYR crosses.Body color in HB was associated with regions with fixed mutations.The simultaneous mutation and superposition of a pair of homologous genes(mitfa)in chromosomes A06 and B06 conferred the reddish color in domesticated HB.Transcriptome analysis of common carp with different alleles of the mitfa mutation confirmed that gene duplication can buffer the deleterious effects of mutation in allotetraploids.This study provides new insights into genotype-phenotype associations in allotetraploid species and lays a foundation for future breeding of common carp.

Cyprinus carpioArtificial selectionColorationmitfaStructural variant

Bi-Jun Li、Lin Chen、Meng-Zhen Yan、Xiao-Qing Zou、Yu-Lin Bai、Ya-Guo Xue、Zhou Jiang、Bao-Hua Chen、Cheng-Yu Li、Qian He、Jian-Xin Feng、Tao Zhou、Peng Xu

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State Key Laboratory of Marine Environmental Science,College of Ocean and Earth Sciences,Xiamen University,Xiamen,Fujian 361102,China

Fujian Key Laboratory of Genetics and Breeding of Marine Organisms,College of Ocean and Earth Sciences,Xiamen University,Xiamen,Fujian 361102,China

College of Fisheries,Henan Normal University,Xinxiang,Henan 453007,China

Henan Academy of Fishery Science,Zhengzhou,Henan 450039,China

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National Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Science Fund for Distinguished Young ScholarsAlliance of International Science Organizations

2019YFE01190003187256132225049ANSO-CR-PP-2021-03

2023

10.24272/j.issn.2095-8137.2022.388

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(2)
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