动物学研究2023，Vol.44Issue(2) ：315-322.DOI:10.24272/j.issn.2095-8137.2022.399

Adult neurogenesis in the primate hippocampus

Ye Li Na-Na Xu Zhao-Zhe Hao Sheng Liu
动物学研究2023，Vol.44Issue(2) ：315-322.DOI:10.24272/j.issn.2095-8137.2022.399
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  • 维普
  • 万方数据

Adult neurogenesis in the primate hippocampus

Ye Li 1Na-Na Xu 1Zhao-Zhe Hao 1Sheng Liu2
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作者信息

  • 1. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510060,China
  • 2. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510060,China;Guangdong Province Key Laboratory of Brain Function and Disease,Guangzhou,Guangdong 510080,China
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Abstract

Adult hippocampal neurogenesis(AHN)is crucial for learning,memory,and emotion.Deficits of AHN may lead to reduced cognitive abilities and neurodegenerative disorders,such as Alzheimer's disease.Extensive studies on rodent AHN have clarified the developmental and maturation processes of adult neural stem/progenitor cells.However,to what extent these findings apply to primates remains controversial.Recent advances in next-generation sequencing technologies have enabled in-depth investigation of the transcriptome of AHN-related populations at single-cell resolution.Here,we summarize studies of AHN in primates.Results suggest that neurogenesis is largely shared across species,but substantial differences also exist.Marker gene expression patterns in primates differ from those of rodents.Compared with rodents,the primate hippocampus has a higher proportion of immature dentate granule cells and a longer maturation period of newly generated granule cells.Future research on species divergence may deepen our understanding of the mechanisms underlying adult neurogenesis in primates.

Key words

Neural precursor cells/Immature granule cells/Sc-RNA-seq

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基金项目

Natural Science Foundation of China(81961128021)

Natural Science Foundation of China(81870682)

National Key R&D Program of China(2022YEF0203200)

Guangdong Provincial Key R&D Programs(2018B030335001)

Science and Technology Program of Guangzhou(202007030011)

Science and Technology Program of Guangzhou(202007030010)

Science and Technology Program of Guangzhou(202007030001)

出版年

2023
动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

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影响因子：0.582
ISSN：0254-5853
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