Adult neurogenesis in the primate hippocampus

扫码查看

原文链接

万方数据
维普

外文摘要：Adult hippocampal neurogenesis(AHN)is crucial for learning,memory,and emotion.Deficits of AHN may lead to reduced cognitive abilities and neurodegenerative disorders,such as Alzheimer's disease.Extensive studies on rodent AHN have clarified the developmental and maturation processes of adult neural stem/progenitor cells.However,to what extent these findings apply to primates remains controversial.Recent advances in next-generation sequencing technologies have enabled in-depth investigation of the transcriptome of AHN-related populations at single-cell resolution.Here,we summarize studies of AHN in primates.Results suggest that neurogenesis is largely shared across species,but substantial differences also exist.Marker gene expression patterns in primates differ from those of rodents.Compared with rodents,the primate hippocampus has a higher proportion of immature dentate granule cells and a longer maturation period of newly generated granule cells.Future research on species divergence may deepen our understanding of the mechanisms underlying adult neurogenesis in primates.

作者：

Ye Li、Na-Na Xu、Zhao-Zhe Hao、Sheng Liu

展开 >

作者单位：

State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510060,China

Guangdong Province Key Laboratory of Brain Function and Disease,Guangzhou,Guangdong 510080,China

基金：

Natural Science Foundation of ChinaNatural Science Foundation of ChinaNational Key R&D Program of ChinaGuangdong Provincial Key R&D ProgramsScience and Technology Program of GuangzhouScience and Technology Program of GuangzhouScience and Technology Program of Guangzhou

项目编号：

81961128021818706822022YEF02032002018B030335001202007030011202007030010202007030001

出版年：

2023

DOI：

10.24272/j.issn.2095-8137.2022.399

参考文献

引证文献

动物学研究

CSTPCDCSCD

影响因子：0.582

ISSN：0254-5853

年,卷(期)：2023.44(2)

Ye Li,Na-Na Xu,Zhao-Zhe Hao,et al.Adult neurogenesis in the primate hippocampus[J].动物学研究,2023,44(2):315-322.DOI:10.24272/j.issn.2095-8137.2022.399.

参考文献量90

[1]	Shi-Huan Wang,Hai-Tao Zhang,Yuan-Yuan Zou,et al.Efficacy and moderating factors of the Early Start Denver Model in Chinese toddlers with autism spectrum disorder:a longitudinal study[J].世界儿科杂志(英文版),2023,19(8):741-752.