首页|Ferrets:A powerful model of SARS-CoV-2

Ferrets:A powerful model of SARS-CoV-2

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The rapid spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in recent years not only caused a global pandemic but resulted in enormous social,economic,and health burdens worldwide.Despite considerable efforts to combat coronavirus disease 2019(COVID-19),various SARS-CoV-2 variants have emerged,and their underlying mechanisms of pathogenicity remain largely unknown.Furthermore,effective therapeutic drugs are still under development.Thus,an ideal animal model is crucial for studying the pathogenesis of COVID-19 and for the preclinical evaluation of vaccines and antivirals against SARS-CoV-2 and variant infections.Currently,several animal models,including mice,hamsters,ferrets,and non-human primates(NHPs),have been established to study COVID-19.Among them,ferrets are naturally susceptible to SARS-CoV-2 infection and are considered suitable for COVID-19 study.Here,we summarize recent developments and application of SARS-CoV-2 ferret models in studies on pathogenesis,therapeutic agents,and vaccines,and provide a perspective on the role of these models in preventing COVID-19 spread.

SARS-CoV-2COVID-19Animal modelsFerretAngiotensin-converting enzyme 2(ACE2)receptor

Yan Zhao、Chang-Le Wang、Zhi-Yun Gao、Hong-Xiu Qiao、Wei-Jie Wang、Xin-Yan Liu、Xia Chuai

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Department of Pathogenic Biology,Hebei Medical University,Shijiazhuang,Hebei 050017,China

Institute of Medicine and Healthy of Hebei Medical University,Shijiazhuang,Hebei 050017,China

Department of Oncology,Hebei Provincial Thoracic Hospital,Shijiazhuang,Hebei 050010,China

S&T Program of HebeiS&T Program of HebeiNatural Science Foundation of Hebei Province,ChinaScience and Technology Project of Hebei Education DepartmentHebei Medical Science Research ProjectChinese Medicine Research Program of Hebei Province

20277705D20372601DH2020206352QN2018150202209732021119

2023

10.24272/j.issn.2095-8137.2022.351

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(2)
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