Abstract
The rapid spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in recent years not only caused a global pandemic but resulted in enormous social,economic,and health burdens worldwide.Despite considerable efforts to combat coronavirus disease 2019(COVID-19),various SARS-CoV-2 variants have emerged,and their underlying mechanisms of pathogenicity remain largely unknown.Furthermore,effective therapeutic drugs are still under development.Thus,an ideal animal model is crucial for studying the pathogenesis of COVID-19 and for the preclinical evaluation of vaccines and antivirals against SARS-CoV-2 and variant infections.Currently,several animal models,including mice,hamsters,ferrets,and non-human primates(NHPs),have been established to study COVID-19.Among them,ferrets are naturally susceptible to SARS-CoV-2 infection and are considered suitable for COVID-19 study.Here,we summarize recent developments and application of SARS-CoV-2 ferret models in studies on pathogenesis,therapeutic agents,and vaccines,and provide a perspective on the role of these models in preventing COVID-19 spread.
基金项目
S&T Program of Hebei(20277705D)
S&T Program of Hebei(20372601D)
Natural Science Foundation of Hebei Province,China(H2020206352)
Science and Technology Project of Hebei Education Department(QN2018150)
Hebei Medical Science Research Project(20220973)
Chinese Medicine Research Program of Hebei Province(2021119)
万方数据