首页|Advances in viral encephalitis:Viral transmission,host immunity,and experimental animal models

Advances in viral encephalitis:Viral transmission,host immunity,and experimental animal models

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Viral infections have led to many public health crises and pandemics in the last few centuries.Neurotropic virus infection-induced viral encephalitis(VE),especially the symptomatic inflammation of the meninges and brain parenchyma,has attracted growing attention due to its high mortality and disability rates.Understanding the infectious routes of neurotropic viruses and the mechanism underlying the host immune response is critical to reduce viral spread and improve antiviral therapy outcomes.In this review,we summarize the common categories of neurotropic viruses,viral transmission routes in the body,host immune responses,and experimental animal models used for VE study to gain a deeper understanding of recent progress in the pathogenic and immunological mechanisms under neurotropic viral infection.This review should provide valuable resources and perspectives on how to cope with pandemic infections.

Neurotropic virusesViral encephalitisMeningeal immunityExperimental animal models

Dan Yang、Xiao-Jing Li、De-Zhen Tu、Xiu-Li Li、Bin Wei

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State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Wuhan,Hubei 430071,China

School of Medicine,Shanghai University,Shanghai 200444,China

State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China

Department of Cardiology,Lanzhou University Second Hospital,Lanzhou,Gansu 730030,China

School of Life Sciences,Shanghai University,Shanghai 200444,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaProgram of Shanghai Academic/Technology Research LeaderStrategic Priority Research Program of the Chinese Academy of Sciences

81825011819300388196116073822XD1400800XDB19030200

2023

10.24272/j.issn.2095-8137.2023.025

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(3)
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