Large animal models of cardiac ischemia-reperfusion injury:Where are we now?

Attaur Rahman ¹Yuhao Li ²To-Kiu Chan ²Hui Zhao ³Yaozu Xiang ⁴Xing Chang ⁵Hao Zhou ⁶Dachun Xu ⁷Sang-Bing Ong⁸

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作者信息

1. Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China;Centre for Cardiovascular Genomics and Medicine(CCGM),Lui Che Woo Institute Innovative Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China;College of Veterinary Sciences and Animal Husbandry,Abdul Wali Khan University Mardan,Mardan,Khyber Pakhtunkhwa 23200,Pakistan
2. Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China;Centre for Cardiovascular Genomics and Medicine(CCGM),Lui Che Woo Institute Innovative Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China
3. School of Biomedical Sciences,CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China;Institute for Tissue Engineering and Regenerative Medicine(iTERM),The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China;SBS Core Laboratory,CUHK Shenzhen Research Institute,Shenzhen,Guangdong 518172,China;Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Comm
4. Shanghai East Hospital,Key Laboratory of Arrhythmias of the Ministry of Education of China,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China
5. Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China
6. Department of Cardiology,Chinese People's Liberation Army General Hospital,Beijing 100853,China;Center for Cardiovascular Research and Alternative Medicine,University of Wyoming College of Health Sciences,Laramie,WY 82071,USA
7. Department of Cardiology,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China
8. Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China;Centre for Cardiovascular Genomics and Medicine(CCGM),Lui Che Woo Institute Innovative Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China;Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases,Hong Kong SAR,China;Hong Kong Hub of Paediatric Excellence(HK HOPE),Hong Kong Child
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Abstract

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical translation. Nonetheless,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models, which are not transferable or reproducible in large animal models due to different factors such as: (ⅰ) complex and varied features of human ischemic cardiac disease (ICD), which are challenging to mimic in animal models, (ⅱ) significant differences in surgical techniques applied, and (ⅲ) differences in cardiovascular anatomy and physiology between small versus large animals. This article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI), as well as the different methods used to induce and assess IRI, and the obstacles faced in using large animals for translational research in the settings of cardiac IR.

Key words

Cardiovascular disorder/Ischemic cardiac disease/Ischemic-reperfusion injury/Large animal model/Myocardial infarction/Translational gap

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基金项目

Early Career Scheme(ECS) 2022/23(CUHK 24110822)

Council of Hong Kong, as well as the Direct Grant for Research 2020/21(2020.035)

Project Impact Enhancement Fund (PIEF)(PIEF/Ph2/COVID/08)

出版年

2023

动物学研究

中国科学院昆明动物研究所中国动物学会

动物学研究

CSTPCDCSCD

影响因子：0.582

ISSN：0254-5853

参考文献量142

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