首页|Large animal models of cardiac ischemia-reperfusion injury:Where are we now?

Large animal models of cardiac ischemia-reperfusion injury:Where are we now?

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Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical translation. Nonetheless,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models, which are not transferable or reproducible in large animal models due to different factors such as: (ⅰ) complex and varied features of human ischemic cardiac disease (ICD), which are challenging to mimic in animal models, (ⅱ) significant differences in surgical techniques applied, and (ⅲ) differences in cardiovascular anatomy and physiology between small versus large animals. This article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI), as well as the different methods used to induce and assess IRI, and the obstacles faced in using large animals for translational research in the settings of cardiac IR.

Cardiovascular disorderIschemic cardiac diseaseIschemic-reperfusion injuryLarge animal modelMyocardial infarctionTranslational gap

Attaur Rahman、Yuhao Li、To-Kiu Chan、Hui Zhao、Yaozu Xiang、Xing Chang、Hao Zhou、Dachun Xu、Sang-Bing Ong

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Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China

Centre for Cardiovascular Genomics and Medicine(CCGM),Lui Che Woo Institute Innovative Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China

College of Veterinary Sciences and Animal Husbandry,Abdul Wali Khan University Mardan,Mardan,Khyber Pakhtunkhwa 23200,Pakistan

School of Biomedical Sciences,CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine,The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China

Institute for Tissue Engineering and Regenerative Medicine(iTERM),The Chinese University of Hong Kong(CUHK),Hong Kong SAR,China

SBS Core Laboratory,CUHK Shenzhen Research Institute,Shenzhen,Guangdong 518172,China

Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Comm

Shanghai East Hospital,Key Laboratory of Arrhythmias of the Ministry of Education of China,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China

Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China

Department of Cardiology,Chinese People's Liberation Army General Hospital,Beijing 100853,China

Center for Cardiovascular Research and Alternative Medicine,University of Wyoming College of Health Sciences,Laramie,WY 82071,USA

Department of Cardiology,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China

Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases,Hong Kong SAR,China

Hong Kong Hub of Paediatric Excellence(HK HOPE),Hong Kong Child

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Early Career Scheme(ECS) 2022/23Council of Hong Kong, as well as the Direct Grant for Research 2020/21Project Impact Enhancement Fund (PIEF)

CUHK 241108222020.035PIEF/Ph2/COVID/08

2023

10.24272/j.issn.2095-8137.2022.487

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(3)
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