首页|Hypoxia tolerance in fish depends on catabolic preference between lipids and carbohydrates

Hypoxia tolerance in fish depends on catabolic preference between lipids and carbohydrates

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Hypoxia is a common environmental stress factor in aquatic organisms,which varies among fish species.However,the mechanisms underlying the ability of fish species to tolerate hypoxia are not well known.Here,we showed that hypoxia response in different fish species was affected by lipid catabolism and preference for lipid or carbohydrate energy sources.Activation of biochemical lipid catabolism through peroxisome proliferator-activated receptor alpha(Pparα)or increasing mitochondrial fat oxidation in tilapia decreased tolerance to acute hypoxia by increasing oxygen consumption and oxidative damage and reducing carbohydrate catabolism as an energy source.Conversely,lipid catabolism inhibition by suppressing entry of lipids into mitochondria in tilapia or individually knocking out three key genes of lipid catabolism in zebrafish increased tolerance to acute hypoxia by decreasing oxygen consumption and oxidative damage and promoting carbohydrate catabolism.However,anaerobic glycolysis suppression eliminated lipid catabolism inhibition-promoted hypoxia tolerance in adipose triglyceride lipase(atgl)mutant zebrafish.Using 14 fish species with different trophic levels and taxonomic status,the fish preferentially using lipids for energy were more intolerant to acute hypoxia than those preferentially using carbohydrates.Our study shows that hypoxia tolerance in fish depends on catabolic preference for lipids or carbohydrates,which can be modified by regulating lipid catabolism.

Hypoxia toleranceCatabolic preferenceLipidCarbohydrateOxidative damage

Qiang Ma、Yuan Luo、Jia Zhong、Samwel Mchele Limbu、Ling-Yu Li、Li-Qiao Chen、Fang Qiao、Mei-Ling Zhang、Qiang Lin、Zhen-Yu Du

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LANEH,School of Life Sciences,East China Normal University,Shanghai 200241,China

Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao,Shandong 266071,China

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou,Guangdong 510301,China

School of Aquatic Sciences and Fisheries Technology,University of Dar es Salaam,Dar es Salaam 60091,Tanzania

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National Natural Science Foundation of ChinaNational Natural Science Foundation of China

3183010232202950

2023

10.24272/j.issn.2095-8137.2023.098

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(5)
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