首页|The known,unknown,and unknown unknowns of cell-cell communication in planarian regeneration
The known,unknown,and unknown unknowns of cell-cell communication in planarian regeneration
扫码查看
点击上方二维码区域,可以放大扫码查看
原文链接
万方数据
维普
Planarians represent the most primitive bilateral triploblastic animals.Most planarian species exhibit mechanisms for whole-body regeneration,exemplified by the regeneration of their cephalic ganglion after complete excision.Given their robust whole-body regeneration capacity,planarians have been model organisms in regenerative research for more than 240 years.Advancements in research tools and techniques have progressively elucidated the mechanisms underlying planarian regeneration.Accurate cell-cell communication is recognized as a fundamental requirement for regeneration.In recent decades,mechanisms associated with such communication have been revealed at the cellular level.Notably,stem cells(neoblasts)have been identified as the source of all new cells during planarian homeostasis and regeneration.The interplay between neoblasts and somatic cells affects the identities and proportions of various tissues during homeostasis and regeneration.Here,this review outlines key discoveries regarding communication between stem cell compartments and other cell types in planarians,as well as the impact of communication on planarian regeneration.Additionally,this review discusses the challenges and potential directions of future planarian research,emphasizing the sustained impact of this field on our understanding of animal regeneration.
PlanariansStem cellsRegenerationCell communication
Jia-Jia Chen、Kai Lei
展开 >
School of Life Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,China
Westlake Laboratory of Life Sciences and Biomedicine,Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province,School of Life Sciences,Westlake University,Hangzhou,Zhejiang 310030,China
Institute of Biology,Westlake Institute for Advanced Study,Hangzhou,Zhejiang 310024,China
Westlake Education Foundation and National Natural Science Foundation of ChinaWestlake Education Foundation and National Natural Science Foundation of China