动物学研究2023，Vol.44Issue(6) ：1132-1145.DOI:10.24272/j.issn.2095-8137.2023.294

Targeting autophagy in Alzheimer's disease:Animal models and mechanisms

Xiao-Wen Zhang Xiang-Xing Zhu Dong-Sheng Tang Jia-Hong Lu
动物学研究2023，Vol.44Issue(6) ：1132-1145.DOI:10.24272/j.issn.2095-8137.2023.294
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Targeting autophagy in Alzheimer's disease:Animal models and mechanisms

Xiao-Wen Zhang 1Xiang-Xing Zhu 2Dong-Sheng Tang 2Jia-Hong Lu1
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作者信息

  • 1. State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao 99078,China
  • 2. Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding,Gene Editing Technology Center of Guangdong Province,Foshan University,Foshan,Guangdong 528225,China
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Abstract

Alzheimer's disease(AD)is an age-related progressive neurodegenerative disorder that leads to cognitive impairment and memory loss.Emerging evidence suggests that autophagy plays an important role in the pathogenesis of AD through the regulation of amyloid-beta(Aβ)and tau metabolism,and that autophagy dysfunction exacerbates amyloidosis and tau pathology.Therefore,targeting autophagy may be an effective approach for the treatment of AD.Animal models are considered useful tools for investigating the pathogenic mechanisms and therapeutic strategies of diseases.This review aims to summarize the pathological alterations in autophagy in representative AD animal models and to present recent studies on newly discovered autophagy-stimulating interventions in animal AD models.Finally,the opportunities,difficulties,and future directions of autophagy targeting in AD therapy are discussed.

Key words

Alzheimer's disease/Aβ metabolism/Tau pathology/Autophagy/Animal models

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基金项目

National Natural Science Foundation of China(82271455)

Guangdong Basic and Applied Basic Research Foundation(2022A1515012416)

Science and Technology Development Fund,Macau SAR(0128/2019/A3)

Science and Technology Development Fund,Macau SAR(0025/2022/A1)

Shenzhen Fundamental Research Program(SGDX20210823103804030)

University of Macau Grants(MYRG2022-00094-ICMS)

National Key R&D Program of China(2021YFA0805901)

National Natural Science Foundation of China(82070199)

Guangdong Basic and Applied Basic Research Foundation(2021A1515220078)

出版年

2023
动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
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被引量4
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