Targeting autophagy in Alzheimer's disease:Animal models and mechanisms

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国家科技期刊平台
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外文摘要：Alzheimer's disease(AD)is an age-related progressive neurodegenerative disorder that leads to cognitive impairment and memory loss.Emerging evidence suggests that autophagy plays an important role in the pathogenesis of AD through the regulation of amyloid-beta(Aβ)and tau metabolism,and that autophagy dysfunction exacerbates amyloidosis and tau pathology.Therefore,targeting autophagy may be an effective approach for the treatment of AD.Animal models are considered useful tools for investigating the pathogenic mechanisms and therapeutic strategies of diseases.This review aims to summarize the pathological alterations in autophagy in representative AD animal models and to present recent studies on newly discovered autophagy-stimulating interventions in animal AD models.Finally,the opportunities,difficulties,and future directions of autophagy targeting in AD therapy are discussed.

作者：

Xiao-Wen Zhang、Xiang-Xing Zhu、Dong-Sheng Tang、Jia-Hong Lu

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作者单位：

State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao 99078,China

Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding,Gene Editing Technology Center of Guangdong Province,Foshan University,Foshan,Guangdong 528225,China

基金：

National Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research FoundationScience and Technology Development Fund,Macau SARScience and Technology Development Fund,Macau SARShenzhen Fundamental Research ProgramUniversity of Macau GrantsNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research Foundation

项目编号：

822714552022A15150124160128/2019/A30025/2022/A1SGDX20210823103804030MYRG2022-00094-ICMS2021YFA0805901820701992021A1515220078

出版年：

2023

DOI：

10.24272/j.issn.2095-8137.2023.294

参考文献

引证文献

动物学研究

CSTPCDCSCD

影响因子：0.582

ISSN：0254-5853

年,卷(期)：2023.44(6)

Xiao-Wen Zhang,Xiang-Xing Zhu,Dong-Sheng Tang,et al.Targeting autophagy in Alzheimer's disease:Animal models and mechanisms[J].动物学研究,2023,44(6):1132-1145.DOI:10.24272/j.issn.2095-8137.2023.294.

被引量1
参考文献量147