首页|Targeting autophagy in Alzheimer's disease:Animal models and mechanisms

Targeting autophagy in Alzheimer's disease:Animal models and mechanisms

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Alzheimer's disease(AD)is an age-related progressive neurodegenerative disorder that leads to cognitive impairment and memory loss.Emerging evidence suggests that autophagy plays an important role in the pathogenesis of AD through the regulation of amyloid-beta(Aβ)and tau metabolism,and that autophagy dysfunction exacerbates amyloidosis and tau pathology.Therefore,targeting autophagy may be an effective approach for the treatment of AD.Animal models are considered useful tools for investigating the pathogenic mechanisms and therapeutic strategies of diseases.This review aims to summarize the pathological alterations in autophagy in representative AD animal models and to present recent studies on newly discovered autophagy-stimulating interventions in animal AD models.Finally,the opportunities,difficulties,and future directions of autophagy targeting in AD therapy are discussed.

Alzheimer's diseaseAβ metabolismTau pathologyAutophagyAnimal models

Xiao-Wen Zhang、Xiang-Xing Zhu、Dong-Sheng Tang、Jia-Hong Lu

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State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao 99078,China

Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding,Gene Editing Technology Center of Guangdong Province,Foshan University,Foshan,Guangdong 528225,China

National Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research FoundationScience and Technology Development Fund,Macau SARScience and Technology Development Fund,Macau SARShenzhen Fundamental Research ProgramUniversity of Macau GrantsNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research Foundation

822714552022A15150124160128/2019/A30025/2022/A1SGDX20210823103804030MYRG2022-00094-ICMS2021YFA0805901820701992021A1515220078

2023

10.24272/j.issn.2095-8137.2023.294

动物学研究
中国科学院昆明动物研究所 中国动物学会

动物学研究

CSTPCDCSCD
影响因子：0.582
ISSN：0254-5853
年,卷(期)：2023.44(6)
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