Helium cryogenic system is applied in the field of ultra-low temperature technology.The high-efficiency and en-ergy-saving helium cryogenic system will greatly promote the development of cryogenic superconducting technology.There-fore,it is significant to study the influence of the main components and optimize the genetic algorithm for the main thermo-dynamic parameters in the system,for improving the refrigeration efficiency and economic benefits and maintaining the sta-bility of the long-term operation.The key parameters affecting the expander and heat exchanger of helium cryogenic system at home and abroad,exergy analysis and genetic algorithm optimization research were reviewed.The existing technical diffi-culties and development trends were summarized.