A radiation hardened 16-bit 25 MS/s pipeline analog-to-digital(ADC)is designed.The architecture of pipeline with 4-bit first stage has been determined based on the consideration of nonideality such as capacitor mismatch and so on,and a novel bootstrapped switch is designed to improve the linearity.A switched-capacitor dynamic bias is proposed to lower the power consumption of the ADC by reducing the average current of amplifier.To meet the requirement of radiation hardness,a radiation hardened reinforcement design of the circuit is implemented according to the mechanism of total ionizing dose and single-event latch-up.This radiation hardened ADC is fabricated in 0.18 μm CMOS process and has area of 2.5 mm2.After irradiation and with the 25 MHz sampling rate,1.8 V power supply and 30.1 MHz sine input,the ADC achieves SNR(signal noise ratio)of 76.7 dBFS,SFDR(spurious-free dynamic range)of 95.1 dBFS,power consumption of 38.6 mW,while the ability of radiation hardness for total ionizing dose is 100 Krad(Si)and the threshold of single-event latch-up is 75 MeV·cm2/mg,which is suitable for space applications.