首页|经颅磁刺激对老年大鼠工作记忆相关跨脑区网络协同作用的影响

经颅磁刺激对老年大鼠工作记忆相关跨脑区网络协同作用的影响

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经颅磁刺激(TMS)因其可以非侵入性地探测和调制大脑皮层兴奋性和功能,已被广泛地应用于改善大脑认知功能等临床神经调控领域.工作记忆的功能实现需要多个脑区的同步活动,该文将行为学与电生理学相结合,通过建立跨脑区的因果网络连接,从记忆相关脑区间协同作用的角度探究不同模式的TMS对大脑认知功能的调控机制.首先对老年威斯塔大鼠分别实施重复经颅磁刺激(rTMS)及间歇性θ节律刺激(iTBS),并设置空白对照组,通过在体多通道微电极阵列采集大鼠工作记忆任务中的局部场电位信号(LFPs);之后基于定向传递函数构建LFPs脑因果网络;最后通过对比行为学结果差异、各脑区因果网络参数等,探索不同模式TMS对老年大鼠工作记忆行为学及脑区之间信息协同作用的影响规律.结果表明,rTMS组和iTBS组大鼠执行正确工作记忆任务的平均天数减少,平均正确率高于空白对照组.经过刺激后,rTMS组和iTBS组前额叶和海马双向网络连接明显增强,信息流强度和因果流向性得到显著提升(P<0.05).因此,rTMS和iTBS模式均能促进老年大鼠海马和前额叶脑区间的信息交流,从而使老年大鼠的工作记忆能力得到改善.
Effect of Transcranial Magnetic Stimulation on Inter-brain Region Networks of Aged Rats during Working Memory Task
Transcranial Magnetic Stimulation (TMS) has been widely used in clinical neuroregulation fields such as improving brain cognitive function because of its ability to non-invasibly detect and modulate the excitability and function of the cerebral cortex. The functional realization of working memory requires the synchronous activity of multiple brain regions. In this paper, it is of great significance to combine behavioral and electrophysiology, establish causal network connections across brain regions, and explore the regulatory mechanism of different modes of TMS on brain cognitive function from the perspective of memory-related brain regions. Firstly, repetitive Transcranial Magnetic Stimulation (rTMS) and intermittent Theta Burst Stimulation (iTBS) are performed in aged Wistar rats, a blank control group is established at the same time, and the Local Field Potentials (LFPs) are collected by an in vivo multichannel microelectrode array during a working memory task. Then, the LFPs brain causal network is constructed based on the directed transfer function. Finally, by comparing the behavioral results and the causal network parameters of each brain region, the effects of TMS on the working memory behavior and the information synergy between brain regions are explored. The results show that the average number of days that rats in the rTMS and iTBS groups performed the correct working memory task is reduced, and the average correct rate is higher than that in the blank control group. After stimulation, the bidirectional network connectivity between prefrontal lobe and hippocampus in the rTMS group and the iTBS group is significantly enhanced, and the strength of information flow and causal streamability are significantly improved (P < 0.05). Therefore, both rTMS and iTBS can promote the communication between the hippocampus and prefrontal cortex, thereby improving the working memory ability of aged rats.

Repetitive Transcranial Magnetic Stimulation (rTMS)Intermittent Theta Burst Stimulation(iTBS)Working memoryBrain causal network

郭苗苗、翟昊迪、吉利辉、王田、徐桂芝

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省部共建电工装备可靠性与智能化国家重点实验室(河北工业大学) 天津 300130

河北省生物电磁与神经工程重点实验室(河北工业大学) 天津 300130

天津市生物电工与智能健康重点实验室(河北工业大学) 天津 300130

河北工业大学生命科学与健康工程学院 天津 300130

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重复经颅磁刺激 间歇性θ节律刺激 工作记忆 脑因果网络

国家自然科学基金国家自然科学基金国家重点研发计划国家自然科学基金国际(地区)合作与交流项目河北省自然科学基金河北省基础研究计划省部共建电工装备可靠性与智能化国家重点实验室(河北工业大学)优秀青年创新基金河北省省级科技计划

51737003517070542022YFC2402203523201050E202120222218963001DEERI_OY2021009225676163GH

2024

10.11999/JEIT230291

电子与信息学报
中国科学院电子学研究所 国家自然科学基金委员会信息科学部

电子与信息学报

CSTPCD北大核心
影响因子：1.302
ISSN：1009-5896
年,卷(期)：2024.46(4)