A DNA Origami Cryptography Scheme Based on Staple Folding
The DNA origami nanostructure encapsulates intricate sequence-folding information,presenting a novel avenue for exploiting cryptography with a vast key space.This paper introduces an encryption strategy that fully realizes the structure-based potential of DNA origami.In contrast to previous approach centered on the folding of DNA origami scaffold,an alternative methodology is introduced based on the nonlinear combination characteristics of staple ensembles.This approach aims to achieve a larger key space by exploring the inherent extensive folding diversity of staple.The key space computational model is delineated into three factors:the binding domain mode,cooperative folding,and independence of staples.These three factors respectively account for the intra-chain distribution,inter-chain arrangement diversity,and sequence specificity of staples.The combination of these factors effectively converts the folding diversity of DNA origami in per unit of geometric space into key space.This strategy represents a cryptography rooted in the principles of biomolecular thermodynamics,offering new possibilities for extending the application scenarios of information security.
DNA origamiDNA nanostructureInformation encryptionKey spaceSelf-assembly