首页|液态金属微球的微观结构与血管栓塞性能研究

液态金属微球的微观结构与血管栓塞性能研究

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本文制备了一种液态金属微球,并对该液态金属微球的微观结构和血管内栓塞效果进行了研究.结果表明:在光学显微镜与电子显微镜下观察到液态金属微球呈球形,在对其元素分析中观察到了镓元素和氧元素;在对兔子耳中央动脉的栓塞实验中,发现液态金属微球成功地阻断了兔子耳中央动脉,导致了兔耳的坏死.当液态金属微球的直径与血管的直径相当时,便会通过物理栓塞方式阻塞血管.同时,液态金属微球因其自身的高密度具有X射线显影性.栓塞前与栓塞后的血液检查和主要器官组织病理表明,液态金属微球有着良好的生物相容性.因此,液态金属微球是一种极具潜在临床应用价值的栓塞材料.
Microstructure and vascular embolic properties of liquid metal microspheres
In this paper,a liquid metal microsphere was prepared.The microstructure and intravascular embolization effect of the liquid metal microsphere were investigated.The result showed that it had a spherical morphology observed by a microscope.Gallium and oxygen elements were detected by elemental analyses.Liquid metal microspheres blocked the central artery of rabbit's ear,leading to necrosis of the rabbit's ear during the embolization experiments on the rabbit's central ear artery.Blood vessels were blocked by physical embolization when the diameter of the liquid metal microspheres was comparable to that of blood vessels.Liquid metal microspheres were X-ray visible due to their high density.Pre-and post-embolization blood tests and histopathology of major organs showed that liquid metal microspheres had good biocompatibility.Therefore,liquid metal microsphere is an embolization material for great potential clinical applications.

liquid metal microspheresembolizationgalliumX-ray visualizationmicrostructure

沈晨宇、甘雅玲、蔣文溪、张维强、陈军歌、梁兴杰、王志军

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中国人民解放军总医院,北京 100853

国家纳米科学中心,北京 100190

军委联合参谋部警卫局卫生保健处,北京 100017

北京航空航天大学医学科学与工程学院,北京 100083

中国科学院大学,北京 100049

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液态金属微球 栓塞 镓 X射线可视 微观结构

国家重点研发计划国家自然科学基金重点项目国家自然科学基金资助项目国家自然科学基金资助项目国家自然科学基金国际合作重点项目中国科学院国际合作项目中央军委后勤保障部专项课题

2021YFA120100032030060822720968220233651861135103121D1KYSB2021000322BJZ53

2024

10.3969/j.issn.1000-6281.2024.03.008

电子显微学报
中国物理学会

电子显微学报

CSTPCD北大核心
影响因子：0.431
ISSN：1000-6281
年,卷(期)：2024.43(3)