Objective To study the effect of ARID1A gene mutation on the clinicopathologic characteristics of endometrioid adenocarcinoma.Methods 43 cases of endometrioid adenocarcinoma diagnosed in the Zhongshan City People's Hospital from January 2021 to December 2021 were selected for whole exome sequencing,11 cases of ARID1A gene mutation were in the experimental group,and 32 cases of non-ARID1A gene mutation were in the control group,and the differences in tumor stage,tumor differentiation,vascular invasion and muscle invasion between the experimental group and the control group were compared.Results The mutation rate of ARID1A in endometrioid adenocarcinoma was 25.6%,among which the mutation rate of ARID1A combined with PTEN was 16.3%,the mutation rate of ARID1A combined with PI3K was 9.3%,the mutation rate of PIK3CA was 65.1%,the mutation rate of PTEN was 60.5%.There was a significant difference between the ARID1A gene mutation group and the control group in terms of depth of myometrial invasion(P＜0.05),but no significant difference in tumor stage,tumor differentiation and vascular invasion between the control group(P＞0.05).Conclusions Excessive activation of PI3K pathway was commonly present in endometrioid adenocarcinoma with ARID1A mutations.The mutation of the ARID1A gene was associated with deep myometrial invasion in endometrioid adenocarcinoma.
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