Coumarin Reduces the Expression of PARP10 to Inhibit HCT116 Proliferation
PARP10 is a member of the ADP-ribosyltransferase family of PARPs and is widely distributed in both the cytoplasm and nucleus of cells.It plays an important role in cell immune response,transcriptional regulation,DNA damage repair,cell cycle regulation,and tumor proliferation.PARP10 promotes tumor cell proliferation and invasion by affecting various signaling pathways and has been found to be involved in the occurrence of malignant tumors such as prostate cancer,breast cancer,gastric cancer,and liver cancer.In this study,we determined that PARP10 also plays an important role in the proliferation of colorectal cancer cells through bioinformatics analysis and biochemical experiments.Inhibiting the expression of PARP10 can significantly inhibit tumor cell proliferation and promote apoptosis.Recently,it has been found that coumarin,a natural bioactive compound,can inhibit the proliferation of tumor cells,but its mechanism of anti-tumor action is unclear.In this study,we found that coumarin can target and decrease the expression of PARP10 protein in colon cancer cells,thereby inhibiting tumor growth.Therefore,this study provides new ideas and directions for colon cancer drug development and tumor treatment.
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