The unique asymmetry of chemistry or composition of external and internal surface for Janus cage allows it to be used as a special microcontainer for separation,enrichment,transport and restricted reactions.To some extent,large aperture of cage can enhance the material transport efficiency between microcontainer and the environment.A two-step method to prepare magnetic organic/inorganic composite Janus cages with large aperture and pH responsiveness was introduced in this paper.Firstly,a magnetic inorganic Janus cage with a well-supported shell and adjustable aperture was prepared by the sol-gel of silane coupling agents and microphase separation of two surfactants at the interface.Then pH-responsive polymer poly diethylaminoethyl methacrylate(PDEAEMA)was grafted on the interior surface of inorganic Janus cage by Cu-mediated controlled radical polymerization to ob-tain functional Janus composite cages.SEM,TEM,FTIR and TGA were performed on composite cages.The size of cages is about 1-3 µm,with tunable pore size from 40 nm to 1 µm.The proportion of polymer in the composite cages is 41.7wt%.Controlled absorption and release of oil and oriented transport of substance can be achieved by chan-ging pH and magnetic manipulation respectively with these composite Janus cages,which means it is pro-mising for drug loading and targeted release in vivo.
large apertureJanus composite cagepH responsivemagnetic manipulationcontrolled absorp-tion and release
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