Basil essential oil(BEO)is a green and safe antibacterial agent.However,the high volatility of BEO has limited its application in the field of antibacterial wound dressings.BEO nanoparticles(BEO@Zein)were prepared by nanoprecipitation method.They were then loaded on the hydrogel based on polyvinylpyrrolidone(PVP)and polyvinyl alcohol(PVA)to form BEO@Zein/PVP-PVA hydrogel wound dressing by freeze-thaw cycle.The micro-scopic morphology and structure of BEO@Zein and hydrogel were characterized.The antibacterial property,mechanical property,swelling and moisturizing,degradability and blood compatibility of hydrogel were studied.The results show that BEO@Zein forms a nano-spherical structure with BEO as core and Zein as shell(mean particle size is 56.3 nm),which significantly reduces the volatility of BEO.BEO@Zein/PVP-PVA hydrogel can release BEO slowly,thus exhibiting excellent slow-release antibacterial property.Therefore,BEO@Zein/PVP-PVA hydrogel has excellent antimicrobial persistence(over 72 h).In addition,the hydrogel shows remarkable antibacterial biofilm property.BEO@Zein/PVP-PVA hydrogel has good mechanical property,swelling and moisturizing,degradability,and blood compatibility.Studies have shown that BEO@Zein/PVP-PVA hydrogel can be used as a good wound dressing material.
NETL
NSTL
万方数据
