生物可降解聚酯/生物陶瓷3D打印骨组织工程支架研究进展
Research advances in 3D printed bone tissue engineering scaffolds based on biodegradable polyester/bioceramics
刘嗣聪 1刘宏治 2殷亚然3
作者信息
- 1. 浙江理工大学 材料科学与工程学院,杭州 310018;浙大宁波理工学院 材料科学与工程学院,宁波 315100
- 2. 浙大宁波理工学院 材料科学与工程学院,宁波 315100
- 3. 浙江理工大学 材料科学与工程学院,杭州 310018
- 折叠
摘要
移植骨植入物是目前治疗骨缺损的公认有效手段之一.生物可降解聚酯/生物陶瓷复合材料结合了生物可降解聚酯的良好力学性能、可降解性能和生物陶瓷的成骨活性,为骨植入物材料提供了新的选择.骨组织工程通过模拟骨骼微环境,加速骨缺损修复.将生物可降解聚酯/生物陶瓷复合材料制备成骨组织工程支架,能进一步加快骨修复进程.3D打印技术的引入能使生物可降解聚酯/生物陶瓷骨组织工程支架的制备过程精确、可重复且具备高自由度,展现出了良好的发展前景.本文阐述了骨组织工程支架应具备的各项性能,总结了近年来国内外学者对生物可降解聚酯/生物陶瓷骨组织工程支架上述性能的改善策略,并展望未来该研究领域的发展方向.
Abstract
Transplantation of bone implants is currently recognized as one of the effective means treating bone defects.Biodegradable polyester/bioceramics composites combine good mechanical and degradable properties of biodegradable polyester with the osteogenic activity of bioceramics,thereby providing a new alternative for bone implant materials.Bone tissue engineering accelerates bone defect repair by simulating the bone microenviron-ment.The fabrication of biodegradable polyester/bioceramics composites into bone tissue engineering scaffolds can further accelerate the process of bone repair,and the introduction of 3D printing technology enables the pre-paration of biodegradable polyester/bioceramics bone tissue engineering scaffolds more precise,reproducible,and flexible,which exhibits very promising development.This review presents physical properties of bone tissue engi-neering scaffolds,summarizes the strategies from domestic and foreign scholars to improve the performance of bone tissue engineering scaffolds based on biodegradable polyester/bioceramics composite in recent years.Besides,the future development perspectives in this field are proposed in the field of research.
关键词
生物可降解聚酯/生物陶瓷/3D打印/骨组织工程支架/骨修复Key words
biodegradable polyester/bioceramics/3D printing/bone tissue engineering scaffolds/bone regene-ration引用本文复制引用
基金项目
国家自然科学基金项目(52373107)
国家自然科学基金项目(51573169)
浙江省自然科学基金项目(LY15E030007)
宁波市"3315计划"创新团队项目()
出版年
2024
NETL
NSTL
万方数据