The two-dimensional layered material not only has a very high load bearing capacity,but also can easily enter the friction contact zone during the friction process by virtue of its ultra-thin thickness.Therefore,they have great research and application potential in reducing friction and wear.As a two-dimensional layered material similar to graphene,Mxenes has a unique structure and rich functional groups.Among them,Ti3C2Tx Mxenes is widely used as a lubricating additive because of its advantages such as shear resistance between low layers,high specific surface area and good dispersion.This paper mainly introduces the main preparation methods of two-dimensional layered Ti3C2Tx,including"top-down"and"bottom-up"preparation routes.The tribological applica-tions and effects of 2D Ti3C2Tx as liquid lubricant additive,solid lubricant coating additive and composite reinforce-ment phase are reviewed,and the lubrication mechanism of Ti3C2Tx is discussed.Further,the development of 2D Ti3C2Tx preparation technology and its application as a new lubrication material are prospected.