聚吡咯/壳聚糖-海藻酸钠复合微球的制备及其药物缓释性能
Preparation of polypyrrole/chitosan-sodium alginate composite microspheres and their slow-release properties
李莎 1张新浩 1贾睿 1罗钰 1邢建宇1
作者信息
- 1. 长安大学 水利与环境学院,西安 710054;长安大学 旱区地下水文与生态效应教育部重点实验室,西安 710054;长安大学 水利部旱区生态水文与水安全重点实验室,西安 710054
- 折叠
摘要
开发新型药物控释复合材料在医药、农业等领域具有重要意义.以壳聚糖和海藻酸钠(CS-Alg)凝胶网络为载体,使用原位氧化法将聚吡咯(PPy)引入其中,制备出PPy/CS-Alg复合缓释材料.通过SEM、FTIR、XPS、UV-vis-NIR对其微观结构、结构组成、光热转换性能进行了研究,并以吲哚丁酸(IBA)为模型药物分子,研究了其缓释性能.结果表明:PPy/CS-Alg微球的多孔微观形貌有利于IBA的装载和释放,原位氧化形成的氧化态PPy在CS-Alg凝胶网络可缓慢还原,并从带正电状态变为不带电状态,该种带电状态的改变,可促使IBA从PPy/CS-Alg微球的凝胶网络中缓慢释放,长效释放率可达到 56.12%.另外基于PPy的光热效应,模拟太阳光照射下PPy/CS-Alg微球的温度可从 26℃最高上升到 39℃,这有利于在微球内部到外部形成温度梯度,进一步增强IBA的缓释能力.以PPy的缓慢还原和光热效应开发的植物生长素IBA控释材料在农业领域具有广阔的应用前景.
Abstract
The development of novel drug controlled release composite materials is of great significance in the fields of medicine and agriculture.Using chitosan and sodium alginate(CS-Alg)gel network as carrier,PPy/CS-Alg composite slow-release material was prepared by in-situ oxidation of polypyrrole(PPy).The microstructure,struc-ture composition and photothermal conversion properties were studied by SEM,FTIR,XPS and UV-vis-NIR.Indole-butyric acid(IBA)was used as a model drug molecule to study its sustained release performance.The results show that the porous morphology of PPy/CS-Alg microspheres is conducive to the loading and release of IBA.The PPy oxidized state formed by in-situ oxidation can be slowly reduced in the CS-Alg gel network,and changes from a positive state to an uncharged state.As a result,IBA can be slowly released from the gel network of PPy/CS-Alg microspheres,with the long-term release rate of 56.12%.In addition,the temperature of PPy/CS-Alg microspheres under simulated sunlight can rise from 26℃to 39℃based on the photothermal effect of PPy,which is conducive to the formation of temperature gradients inside and outside the microspheres and further enhancing the slow-release of IBA.The controlled release material of auxin IBA based on the slow reduction and photothermal effect of PPy has broad application prospects in the agricultural field.
关键词
复合凝胶微球/聚吡咯/吲哚丁酸/光热效应/药物释放Key words
composite gel microspheres/polypyrrole/indolebutyric acid/photothermal effect/drug release引用本文复制引用
基金项目
陕西省教育厅科学研究计划项目(22JE003)
陕西省自然科学基础研究计划项目(2020JM-226)
出版年
2024
NETL
NSTL
万方数据